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JohnArnoldFndtn's profile
John Arnold
John Arnold
John Arnold
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@JohnArnoldFndtn

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John ArnoldVerified account

@JohnArnoldFndtn

Co-chair of Arnold Ventures. Eternally fighting status quo bias.

Houston
arnoldventures.org
Joined October 2013

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    John Arnold‏Verified account @JohnArnoldFndtn 5 Jun 2019

    FDA is under intense pressure to approve drugs shown to be safe but with unproven efficacy. But doing so sells false hope to desperate patients, takes $ that could be spent on proven treatments, causes unnecessary side effects, & raises insurance premiums.https://www.bloomberg.com/news/articles/2019-05-30/too-many-medicines-simply-don-t-work …

    8:12 AM - 5 Jun 2019
    • 64 Retweets
    • 146 Likes
    • Mohamed ElSeidy Adam W Gaffney Fabiola Vélez Javier B. Tanto por decir Vicky Galvez🎭 https://ligautismo.org Connie Walyaro Oil Trader María Alejandra Ospino
    7 replies 64 retweets 146 likes
      1. New conversation
      2. Dudley‏ @SmellsBadInHere 5 Jun 2019
        Replying to @JohnArnoldFndtn

        Key FDA committees are well paid by pharma to approve drugs regardless of their usefulness or safety in order to boost profits, stock price and C Suite compensation.

        1 reply 0 retweets 0 likes
      3. Dudley‏ @SmellsBadInHere 5 Jun 2019
        Replying to @SmellsBadInHere @JohnArnoldFndtn

        This is why pharma stk prices get the boost when drugs enter Phase 2...because Phase 3 is a foregone conclusion...because everyone knows it's rigged. Stk market is merely front running FDA rubber stamp that was bought by pharma.

        0 replies 0 retweets 0 likes
      4. End of conversation
      1. Kristin 🧋‏ @k_a_lindquist 5 Jun 2019
        Replying to @JohnArnoldFndtn

        Not a refutation, but of note that industry seems to run more rigorous trials (on avg) than the NIH (taking blinding/randomization as proxy for rigor). IMO we need more Phase IV, higher rigor overall, but avoid more time/cost burdens on Phase I-III. https://www.bmj.com/content/361/bmj.k2130 …pic.twitter.com/QCa9vyikDU

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      1. New conversation
      2. Frank Baitman‏ @frankbaitman 5 Jun 2019
        Replying to @JohnArnoldFndtn @matthewherper

        As an Entrepreneur-in-Residence at the FDA, one of our guiding principles was to be the “regulatory body of choice for drug and device manufacturers”. FDA approval is the Gold Standard for safety and efficacy. It'd be a shame to pass that torch to other nations’ regulators.

        1 reply 0 retweets 1 like
      3. John Arnold‏Verified account @JohnArnoldFndtn 5 Jun 2019
        Replying to @frankbaitman @matthewherper

        I’m not following the connection as to whether FDA should require efficacy for approval.

        1 reply 0 retweets 0 likes
      4. Show replies
      1. Silent Cal‏ @KralcTrebor 5 Jun 2019
        Replying to @JohnArnoldFndtn

        Best long run policy would be full deregulation. No licensure and no govt restriction on treatment. Govt as purchaser would set standards for disclosure it requires to buy for Medicare / Medicaid / VA. Otherwise allow full chaos of decentralized decision making. It works well.

        0 replies 0 retweets 0 likes
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      1. Kirill Karlin, MD‏ @kirillkarlin 5 Jun 2019
        Replying to @JohnArnoldFndtn

        Great to finally see bigger media outlets picking up this topic!

        0 replies 0 retweets 0 likes
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      1. Brian Shields‏ @MrPug94 6 Jun 2019
        Replying to @JohnArnoldFndtn @matthewherper

        You might want to peel back the onion on the NSCLC approvals of Tarceva and Avastin. If EGFRmut had not been ignored in Tarceva initial approval, Avastin May never have been approved as well. These approvals were turning points in the $DNA stock price legend. #TrialDesign

        0 replies 0 retweets 0 likes
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      1. New conversation
      2. Gregg Gonsalves‏Verified account @gregggonsalves 12 Jun 2019
        Replying to @JohnArnoldFndtn

        We learned in the AIDS epidemic-particularly in the early days-that getting drugs on the market more quickly was grossly insufficient. 1/

        1 reply 0 retweets 0 likes
      3. Gregg Gonsalves‏Verified account @gregggonsalves 12 Jun 2019
        Replying to @gregggonsalves @JohnArnoldFndtn

        We ended up having a decade or more of broad uncertainty about the benefits of the drugs we put in our bodies. 2/

        1 reply 0 retweets 0 likes
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