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Prikvačeni tweet
Starting sabbatical in Bay Area. Last sabbatical I ambitiously began writing a book on economics and finance for the general reader https://www.amazon.com/Bypass-Wall-Street-Biologists-Guide/dp/0997010010/ …. Ouch. So this time my only ambition is to hang out, talk to new people and see what happens, preferably within biology.
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Protein abundance should affect selection, not sample preparation errors, so this is evidence that the higher error rate in E. coli than S. cerevisiae is real.
@etienne_rajon and I predicted this countintuitive result in 2011 from drift barrier theory.https://www.pnas.org/content/108/3/1082 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Curves like this have the potentially serious problem of making errors/reads a function of a correlate of reads. We directly a Poisson error function, handling both this problem and heteroscedasticity. Binned data are to show linear shape only.pic.twitter.com/8vGe7ClsQ3
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S. cerevisiae has a much lower error rate, and no relationship - except for the C->U errors, which were measured with a better protocol, and are at high enough rates for selection to care.pic.twitter.com/xI4B6V0FTq
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The E. coli relationship was steeper for G->A mistranscription events. It was non-existent for C->U because too much deamination happened during sample prep rather than biologically.pic.twitter.com/MPS5RwK3Fp
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Our latest paper documents patterns in transcriptional error rates. When they are high, there is gene-level selection to reduce them in highly expressed genes. When they are low, they are equal across genes. https://academic.oup.com/gbe/article/12/1/3754/5678788 …
@GenomeBiolEvolPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Joanna Masel proslijedio/la je Tweet
I'm hiring a postdoc in computational population genomics. They will contribute to an NIH-funded project to develop and apply methods for inferring novel models of natural selection. To learn more, contact me or visit http://gutengroup.mcb.arizona.edu .
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Do we seriously need to convert our latex manuscript into Word before we can submit it to Proceedings B
@royalsociety, just for page count? https://royalsociety.org/journals/authors/author-guidelines/ … This is an insane amount of work, and we are reconsidering journal choice.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Joanna Masel proslijedio/la je Tweet
Happy 2020! With the holidays behind us, wanted to highlight a few key take-aways from our preprint: https://www.biorxiv.org/content/10.1101/2019.12.21.886093v1 …. Our study focuses on a basic question: how do gut microbial communities respond to routine antibiotic treatments?
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Joanna Masel proslijedio/la je Tweet
"the resulting epidemic of subclinical lead poisoning could have reduced the number of children with truly superior intelligence (IQ scores > 130 points) by more than 50% and, concurrently, caused a more than 50% increase in the number of children with IQ scores < 70" 2/3pic.twitter.com/qkcQkd2LmN
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Joanna Masel proslijedio/la je Tweet
Registrations are now open for
#SMBE2020 You can join@OfficialSMBE at the same time to be part of a great scientific society and enjoy an even more affordable meeting. http://smbe2020.org/registration/ https://twitter.com/landrychristian/status/1197863963192647681 …
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Joanna Masel proslijedio/la je Tweet
"random genetic drift" - which doesn't equal the drift term in a diffusion equation (mathematically) or in common usage (watching the clouds drift by...)https://twitter.com/CicadaScience/status/1205259393413066753 …
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Joanna Masel proslijedio/la je Tweet
*Super* excited for
#ISEB2019. See program here: https://sites.google.com/view/iseb2019/programme …https://twitter.com/ChipmanLab/status/1204436373970866176 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Joanna Masel proslijedio/la je Tweet
This is like exactly the kind of situation where people are afraid to do a randomized controlled trial and exactly the kind of situation showing why we should be doing them cc
@JoannaMaselhttps://twitter.com/michaelhoffman/status/1203007407888093184 …
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Joanna Masel proslijedio/la je Tweet
We reconstructed regulatory networks for yeast promoters in this way, and found that weak regulatory interactions explain the vast majority of expression. These two promoters encode the same expression level, but using very different regulatory strategies!pic.twitter.com/16TPem5jCa
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Joanna Masel proslijedio/la je Tweet
Most yeast TFs (and human too), have low information content and so are predicted to occur often by chance in random DNA. How often? The average random 80-mer has about 138 binding sites for 68 different TFs (!)pic.twitter.com/ufxd1NXta7
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Joanna Masel proslijedio/la je Tweet
In collaboration with
@betulland,@skryazhi, Ross Monasky and Shohreh Sikaroodi, I am very happy to present our latest preprint "Evolutionary stalling in the optimization of the translation machinery". (1/9)https://www.biorxiv.org/content/10.1101/850644v1 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Joanna Masel proslijedio/la je Tweet
In another thread, I go through the science of my new preprint (https://www.biorxiv.org/content/10.1101/850644v1 …). Here I want to talk about the journey it took to get it to this stage (1/12)
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Joanna Masel proslijedio/la je Tweet
1. For the last few years we've been hearing a lot about *evidence-based teaching* practices. In principle, I'm a big fan of using evidence to improve my teaching. In practice, the majority of the evidence we are presented with is deeply problematic.
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Abstract submission is now open for
#smbe2020 http://smbe2020.org/abstracts/abstract-submission/ …, and our symposium there looks forward to receiving your submissions on the topic of mutation load!pic.twitter.com/01N73qg62U
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Joanna Masel proslijedio/la je Tweet
What do you expect evolution to look like in a microbial population? Check out our new study offering a view of that over 1000 generations in yeast in the lab. co-led by
@alex_nguyen_ba,@jireva, in@MichaelMDesai 's labhttps://www.nature.com/articles/s41586-019-1749-3 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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