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JedMSP's profile
Jedidiah Carlson
Jedidiah Carlson
Jedidiah Carlson
@JedMSP

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Jedidiah Carlson

@JedMSP

Population genetics, doom metal, anti-racism, metaresearch, & eye-rolling. He/Him.

Minneapolis
jedidiahcarlson.com
Joined May 2010

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    Jedidiah Carlson‏ @JedMSP 25 Feb 2018

    This comment got me thinking how absolutely bonkers DNA replication is when you try to explain it with any sort of metaphor. A thread.pic.twitter.com/bqJRqqKppB

    1:48 PM - 25 Feb 2018
    • 1,973 Retweets
    • 3,226 Likes
    • Carl Zurhorst Roshni Biswas Adam's pimple kpm Kedar Natarajan Mauricio Ortega Ruby Dawes Phoebe Parrish Kira Mourão
    44 replies 1,973 retweets 3,226 likes
      1. New conversation
      2. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        First, imagine that your 3GB file is cut into 23 pieces and stored on 3 feet of magnetic tape. Data redundancy is important, of course, so let's double it into 46 pieces (6ft) for good measure.pic.twitter.com/UDZp1xwHLD

        3 replies 19 retweets 210 likes
        Show this thread
      3. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        Each of the 46 pieces of tape is actually two identical but complementary pieces, encoding the same data, but glued together in opposing orientation.pic.twitter.com/iotrVlExTu

        4 replies 8 retweets 151 likes
        Show this thread
      4. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        Each piece is twisted up like a rotini noodle, wrapped around a few million tiny marbles for organization, then twisted again, over and over until it's a rat's nest of data that can fit into the period of this sentence.pic.twitter.com/zfqWXIDIKF

        1 reply 8 retweets 154 likes
        Show this thread
      5. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        We toss that tangle of tape into a vicious environment where little gnomes with garden shears are constantly trying to cut it apart and insert the gnomAD Mixtape Vol. 2, UV radiation melts it, and the sysadmin is a chain smoker.pic.twitter.com/8SPGAtRXxW

        2 replies 24 retweets 275 likes
        Show this thread
      6. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        Now we need to copy this hairball of information, and the only way to do so is to clamp on a little roomba running a Ctrl+C/Ctrl+V script.pic.twitter.com/sdhOxoTWII

        3 replies 16 retweets 226 likes
        Show this thread
      7. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        Before this copy-roomba can do anything, it needs to recruit a Toy Story-esque pantheon of misfit toys to unravel the tape, unglue it from the marbles, and separate the complementary strands.pic.twitter.com/kzQXAuX7CK

        1 reply 9 retweets 170 likes
        Show this thread
      8. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        Once we untangle our tape into something roughly linear, the copy-roomba is good at its job, but will gag on any tape that has been nicked, cut, kinked, sun-damaged, or overheated.pic.twitter.com/nKCR083MFv

        2 replies 10 retweets 160 likes
        Show this thread
      9. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        When that happens, it will call for help from a smaller, stupider copy-roomba that will copy a bit of gibberish to get past the broken tape.pic.twitter.com/p0k9c8i6IO

        3 replies 11 retweets 183 likes
        Show this thread
      10. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        If the original copy-roomba stays stuck, the entire strand of data will be corrupted, and the system will crash. Better to make an error or two til you hit that all-important EOF signal.pic.twitter.com/LdMOB1ElGu

        1 reply 6 retweets 137 likes
        Show this thread
      11. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        Meanwhile, another version of the copy-roomba is doing the same thing, moving in the opposite direction on the piece of complementary tape.pic.twitter.com/0ejd3FFeas

        3 replies 8 retweets 137 likes
        Show this thread
      12. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        Almost immediately after this happens, the displaced marbles need to be put back exactly as they were...did I mention that their spacing and the type of marble used is also important for data fidelity?pic.twitter.com/hDNZ7AlQCQ

        2 replies 6 retweets 136 likes
        Show this thread
      13. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        Now repeat this 10 quadrillion times over your lifetime. Oh, also, all the bits of data are quarternary. Oh, and the timing of each copy process has to be elaborately orchestrated to ensure the server rack doesn't explode.pic.twitter.com/xXf2bRqbl1

        2 replies 9 retweets 172 likes
        Show this thread
      14. Jedidiah Carlson‏ @JedMSP 25 Feb 2018

        And this is why (to me at least) the mutation and repair of DNA is the most fascinating topic in all of biology. If life in 2018 seems kinda shitty, remember that at the molecular level, it's still beautiful, and studying it is one hell of a fun way to spend your time.pic.twitter.com/ENu36ckoAn

        30 replies 74 retweets 863 likes
        Show this thread
      15. End of conversation

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