Postdoctoral researcher with 
Table 2 (listing novel hits) seems to have a mistake. One of the hits is rs1426654 (SLC24A5), which is a well-known pigmentation variant.
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Huge meta-analysis of hair color in Europeans identifies 13 novel loci: Collectively, assoc SNPs explain 34.6% of red hair, 24.8% of blond hair, and 26.1% of black hair heritability. Hair (and skin and eye) pigmentation ARE complex polygenic traits https://www.nature.com/articles/s41588-018-0100-5 …pic.twitter.com/ILcCQ7dUNv
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Also, they report 111 novel variants, not 13...
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Just asking: why does each hair color have its own heritability? Do they have separate biological mechanisms?
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According to the authors: "... although hair pigmentation spans a spectrum from very bright (blond) to very dark (black), the genetic mechanisms do not always follow this linear scale, as red hair color often has unique predisposing genetic factors."
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Thats all they can explain for hair color a minority of the variance? I thought the hair thing was already sorted.
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Same here
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I just looked at the Y axis of that plot again. It's a log-log plot: it has the *exponents* of the P values as a log scale.
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Hmm... p-values indicating importance, reciprocal probabilities greater than the number of people on the planet (presumably because
@23andMe), no discussion of the highest beta value from the "meta-analysis", and a single-population analysis. Nope, nothing wrong with that study.Thanks. Twitter will use this to make your timeline better. UndoUndo
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