I mean it in the Tinbergen sense. What is this thing for vs how does it do it. There are different kind of can openers that do the ~same thing but with different designs and mechanisms. So if you only look at whether the can was opened you didn't learn anythign about mechanism.
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In C. elegans, it is useful for hypothesis generation and for realizing how ubiquitous signaling relationships that ignore the connectome are. Does very little work constraining circuit models.
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The best sketch I have online is this: https://arxiv.org/abs/1404.5103 Think of it as layering a lot of in-situ spatial transcriptomics & proteomics, on top of connectivity, probably all obtained optically & with the benefit of expansion microscopy... would include modulatory receptors.
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Hey I think I see my 8th grade locker combination!
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