Vinod Jaskula-Ranga

@JaskulaRanga

Scientist, Founder/CEO Biotech Startup, CRISPR/AAV Delivery .

Cambridge, MA
hunterian.com
Dołączył grudzień 2018
9 zdjęć lub filmów Zdjęcia i filmy

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  1. 22 lis

    Incredible. Persons of the Year

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  2. 16 lis

    Incredible contribution from !

    Here's an underappreciated protein engineering trick behind the and vaccines: before the pandemic, Jason McLellan et al figured out a way to stabilize the spike protein in the prefusion form that antibodies target.
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  3. 13 lis

    A PCR test that can identify proteins would be...magical

    W odpowiedzi do @PPathole @cleantechnica
    A good PCR test should identify if I have the cov2 spike proteins, although I have heard some low accuracy numbers for those too. Hard to get a straight answer. False positives will roughly scale with # of tests & daily test rate has gone ballistic:
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  4. 11 lis

    Such a poignant remark - and on a national holiday to commemorate sacrifice and service to the country - that wearing a mask to protect one another is not a compelling enough reason

    The CDC just changed its guidance around mask-wearing to say that masks protect the wearer as well as others around them, presumably to encourage mask wearing. This is notable for what it says about our national character.
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  5. 11 lis

    With so much succeeding, I just don’t see how the country will manage...

    Everyone told me is the Florida of Canada, but it turns out it’s the :
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  6. 7 paź

    What a nice memory seeing a picture of my old bench from a day that I’ll never forget! And cheers to all these Laureates making herstory!

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  7. 7 paź

    A wonderful day for and !! Big Congratulations to Jennifer Doudna and Emmanuelle Charpentier for their extraordinary contributions that will have far-ranging consequences in science and medicine!!

    2020 Chemistry Laureates Emmanuelle Charpentier and Jennifer Doudna discovered one of gene technology’s sharpest tools: the CRISPR/Cas9 genetic scissors. Using these, researchers can change the DNA of animals, plants and microorganisms with extremely high precision.
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  8. 20 wrz

    There is another amazing nugget in this paper – it is also the first report and demonstration of ethanol precipitation. Perhaps it is with this enduring laboratory use – and not blenders – that is the true testament to the lasting elegance of their work. /11

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  9. 20 wrz

    Furthermore, the material they purified (DNA) had high biological activity that could be demonstrated by titration down to 0.003µg. In 1944, Avery, McCarthy, and MacLeod determined that DNA is the genetic material. /10

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  10. 20 wrz

    They went on to show that transformation was insensitive to proteases, RNases, yet highly sensitive to DNase. /9

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  11. 20 wrz

    Through a biochemical tour de force Avery, McCarthy, and MacLeod deduced the C, H, N, and P content, matching the theoretical composition of DNA to an incredible accuracy - in one swoop showing the purity of their sample, and that it couldn't be protein, carbs, or lipids either/8

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  12. 20 wrz

    It builds upon the work of Griffith (1928) that demonstrated bacterial transformation by another set of elegant experiments that's worth reading /7

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  13. 20 wrz

    The Avery, McCarthy, and MacLeod paper (1944) is a true work of elegance that should be read in full by those interested - it is here where DNA was elucidated as the genetic material /6

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  14. 20 wrz

    H/C's subsequent experiment looking at progeny, however, went significantly farther. They showed that the infectious agent transferred to progeny was only 1% S35 and 30% for P32, but even then, it is anything less than definitive and conclusive. /5

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  15. 20 wrz

    The data - at best - only suggests that DNA is the genetic material. There's simply no way to conclude that the 25% of protein did not contain any genetic material. As one might expect, a blender is messy and consequently, it’s hard to see elegance in the actual data. /4

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  16. 20 wrz

    According to Hershey-Chase, "75 to 80 per cent of the phage sulfur can be stripped from infected cells by violent agitation," and "only 21 to 35 percent" of P32 (phage DNA). The data was in no way a clean and clear determination. /3

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  17. 20 wrz

    First off, S35 radiolabels proteins and P32 radiolabels DNA. H/C's objective was to label phage with either isotope and see which isotope transferred to bacteria, thereby identifying the genetic material; the blender was to disrupt the particles after a limited interaction. /2

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  18. 20 wrz

    Hershey-Chase was actually a messy experiment, but the myth of its elegance persists, perhaps due to that gimmicky prop (and Nobel). The Avery, McCarthy, and MacLeod paper is truly one of the most elegant papers, and the first elucidation of DNA as the hereditary material. /1

    The Hershey-Chase experiment is one of the most elegant and consequential experiments in the history of molecular biology. The key instrument was a Waring blender still on display at CSHL.
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  19. podał/a dalej
    11 wrz

    I know the technical PCR nerdery is hard for the general public. I feel this whenever I read a hardcore immunology paper! A few thoughts on the concerns about PCR... PCR threshold cycles are test-/machine-/reagent-/kit-/lab-/handler-/sample site-/sample storage/sample handling/..

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  20. 1 wrz

    Finally thinking ahead!

    FDA Promises To Fast-Track Cure For Side Effects Of Fast-Tracked Covid Vaccine
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