James Lingford

@JamesLingford

Biochemist in lab | evolution, enzymes & entropy | protein engineering | glycoproteins | Pink Floyd mega-fan

Melbourne, Australia
Vrijeme pridruživanja: ožujak 2014.

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  1. Prikvačeni tweet
    5. sij 2019.

    There is an amazing evolutionary biology paper out this week in Science: DNA fragility in the parallel evolution of pelvic reduction in stickleback fish Let’s look at what they did.

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  2. proslijedio/la je Tweet

    "A clearer understanding of genetic relationships of childhood maltreatment, incl particular abuse subtypes, with a range of phenotypes, may ultimately be useful in in developing targeted treatment and prevention strategies." Unethical and irresponsible.

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  3. proslijedio/la je Tweet
    1. velj

    Based on the content of my mentions, I feel like I need to further debunk crazy / HIV conspiracy preprint. This is a thread doing so. 1/9

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  4. proslijedio/la je Tweet
    1. velj

    I've been seeing this kind of response to my paper from would-be critics claiming I show 20% of the racial IQ gap is genetic and claiming it supports race science (and that I am a race scientist). While this criticism is obviously in bad faith I want to address any ambiguity here

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  5. proslijedio/la je Tweet
    31. sij

    I've checked it because this claim that HIV inserts in & not fortuitous is insane. So I aligned the sequences & those inserts are real. However I've blast those peptides & founds > 100 hits from various organisms. In my view - HIV link not ascertained.

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  6. proslijedio/la je Tweet
    1. velj

    The mere claim that such short inserts support nCoV origins "unlikely to be fortuitous in nature" [sic] is already highly suspect. This is a classic case of searching for lost keys only under a lamppost. A fearful world does not need to fuel conspiracy theories with bad analyses.

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  7. proslijedio/la je Tweet
    31. sij

    These short inserts do indeed exist in relative to its closest sequenced relative (BetaCoV/bat/Yunnan/RaTG13/2013, seen here ). However, a simple BLAST of such short sequences shows match to a huge variety of organisms. No reason to conclude HIV.

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  8. proslijedio/la je Tweet
    31. sij

    Please see the comments coming in from expert biologists like explaining why these insertions are coincidence and highly unlikely to be from HIV

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  9. proslijedio/la je Tweet
    28. sij

    Considering Charles Murray's new book comes out tomorrow it's good timing that this little side-project I took on (in the middle of my comprehsensive exams!) just came out.

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  10. proslijedio/la je Tweet
    26. sij

    I wrote this, a selection of a couple of ideas from my new book please share widely, there’s a storm coming... 👊🏽

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  11. proslijedio/la je Tweet
    23. sij

    I study genocide. It's been a theme in my academic endeavours for nearly 30 years. More accurately, I study the conditions in the lead up to genocide, be they cultural, social, political, economic, etc... 1/n

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  12. 24. sij

    Evolutionary biology educators & communicators used to deal with creationist myths & misconceptions. Now they have to deal with whatever the hell this hyper-adaptationist BS is. How times have changed.

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  13. proslijedio/la je Tweet
    22. sij

    Great to see our study on ligand flexibility ! We report how to dissect contributions from direct contacts and ligand flexibility to complex stability. Congrats to everyone involved + !

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  14. proslijedio/la je Tweet
    20. sij

    Systematically mapping protein-drug interactions in vivo could greatly expedite and improve drug discovery. Together with Cellzome we adapted TPP to the in vivo setting and find organ-specific drug target interactions and protein interaction states.

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  15. 21. sij

    Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide Beautiful work here from

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  16. 20. sij

    Scientists should approach empirical hypotheses responsibly w/ a social & historical awareness. To hypothesise "some races may have a genetic predisposition for low-IQ/crime" cannot be passed off as benign. It can & has been weaponised politically. See Philip Kitcher:

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  17. proslijedio/la je Tweet
    18. sij

    Gene expression levels are continuous rather than binary. To access biological phenotypes along such a continuum, we developed a method to titrate gene expression using systematically attenuated CRISPR guide RNAs. Check out our work in

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  18. 17. sij

    Predictable properties of fitness landscapes induced by adaptational tradeoffs 🤯

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  19. proslijedio/la je Tweet
    16. sij

    It's time to replace λBeta in MAGE, DIvERGE and ssDNA recombineering! By analyzing 100s of proteins, we have identified 2 that allow E.coli oligo-recombineering with up to 50% efficiency, increase multiplexability + allow MAGE in P. aeruginosa – mjesto: Harvard Medical School New Research Building

    , , i još njih 6
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  20. 16. sij

    Evolutionary trend toward kinetic stability in the folding trajectory of RNases H 'despite large sequence divergence, the overall folding pathway is conserved over billions of years of evolution'

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  21. proslijedio/la je Tweet
    13. sij

    There is an article in today against me . My timeline is now filled with insults and questions. I will not be responding individually, hence this thread. 1/

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