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JamesEKHildreth's profile
James E.K. Hildreth
James E.K. Hildreth
James E.K. Hildreth
@JamesEKHildreth

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James E.K. Hildreth

@JamesEKHildreth

President and CEO, Professor of Internal Medicine, Meharry Medical College, HIV researcher

Nashville, TN
mmc.edu
Joined October 2013

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    James E.K. Hildreth‏ @JamesEKHildreth 30 Nov 2021

    FDA AMDAC has voted 13 yes, 10 no for EUA for Merck's molnupiravir COVID-19 drug. I voted no. Inclusive data on mutagenic potential and concerns over generating troublesome SARS-CoV2 variants were not addressed to my satisfaction. Drug has modest 30% reduction in COVID-19 risk.

    2:15 PM - 30 Nov 2021
    • 258 Retweets
    • 630 Likes
    • f W. T. Cheryl mirla (she/her) η άσωτη κόρη(matricule 14854) блудная дeвочка ⚫🔥Antoinette Roquentin 🧠🔥💘🏳️‍🌈 Steve M Nick Sharpianni Zacarin
    47 replies 258 retweets 630 likes
      1. New conversation
      2. The Architect‏ @TheArch01196450 30 Nov 2021
        Replying to @JamesEKHildreth @megtirrell

        What about the mortality benefit of 9 vs 1 (Pt with metastatic liver cancer who died of bacterial infx). Plus the ability to work against multiple variants in the setting of omicron. New variants make monoclonal antibodies less effective as evidenced by regeneron CEO comments.

        1 reply 0 retweets 3 likes
      3. EMJAYDOUBLEU‏ @MattWil97277168 30 Nov 2021
        Replying to @TheArch01196450 @JamesEKHildreth @megtirrell

        The data also suggested Molnupiravir was less effective against Delta. How effective do you think it will be against Omicron? They never satisfactorily answered how the second half LPD of the trial was so ineffective…Delta seems the only real answer.

        0 replies 1 retweet 8 likes
      4. End of conversation
      1. jf‏ @jfredwing 30 Nov 2021
        Replying to @JamesEKHildreth @matthewherper

        Look at Gilead and MTNB oral Resdemsiver using MTNB LNC platform to deliver it safely. Have you thought or know about it??

        0 replies 0 retweets 0 likes
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      1. Jim - live creatively - Galatians 6:1‏ @TNkeffer 30 Nov 2021
        Replying to @JamesEKHildreth

        Thanks for participating in this!

        0 replies 0 retweets 3 likes
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      1. P‏ @1985muenchen 30 Nov 2021
        Replying to @JamesEKHildreth

        Good man. You made the right call.

        0 replies 0 retweets 7 likes
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      1. Benjamin Ryan‏Verified account @benryanwriter 30 Nov 2021
        Replying to @JamesEKHildreth

        Benjamin Ryan Retweeted Benjamin Ryan

        https://twitter.com/benryanwriter/status/1465810567357153283 …

        Benjamin Ryan added,

        Benjamin RyanVerified account @benryanwriter
        None of the FDA panelists debating molnupiravir's authorization have raised the question of whether the existence of an oral antiviral might discourage people from taking monoclonal antibodies that boast a much higher efficacy and thus reduce the chance of success with treatment.
        Show this thread
        0 replies 0 retweets 6 likes
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      1. David Wood‏ @davidinmoscow 30 Nov 2021
        Replying to @JamesEKHildreth

        Thank you for your work on this. Clearly a difficult decision.

        0 replies 0 retweets 2 likes
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      1. Raymond schinazi‏ @drugbuster21 30 Nov 2021
        Replying to @JamesEKHildreth

        Courageous vote. Well done. The question to the panel should have been “based on the data presented today, if you had symptoms of Covid-19 would you take these pills to prevent disease progression and possibly death?”

        0 replies 1 retweet 21 likes
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      1. Phillyboy‏ @Phillyboy1776 30 Nov 2021
        Replying to @JamesEKHildreth @DrLeanaWen

        I am in your camp, the reduction is not significant and the associated risk is an intrinsic threat to all.

        0 replies 0 retweets 7 likes
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      1. Douglas E‏ @DouglasE4True 30 Nov 2021
        Replying to @JamesEKHildreth @DrLeanaWen

        Profit motive must no longer be a part of health care in the USA. Only highly effective remedies with low side effects should be allowed in production.

        0 replies 1 retweet 2 likes
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