Jacob S. Aday, Ph.D.

@JacobSAday

Experimental Psychologist | Postdoc researching psychedelics | Michigander

San Francisco, CA
researchgate.net/profile/Jacob_…
Joined June 2020
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  1. Jan 22

    Some general thoughts on the response to this: 1. Many need to actually read the article 2. Language is important (notice: “suggests” and “may” in my original post) 3. By the same token, maybe the title could have been “Challenging the narrative” instead of “Debunking the myth”

    Does MDMA actually lead to mood drop in the days after dosing? Our new study in Journal of Psychopharmacology with clinically administered MDMA suggests this may be a myth 🧵👇
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  2. Jan 20

    Very excited to finally share this work and honored to have gotten the chance to work on this with my UK colleagues, Val Curran and Steve O'Brien.

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  3. Jan 20

    The results of course require further follow-up and validation, but we are excited to challenge the narrative around this aspect of MDMA use and are interested in hearing others' thoughts.

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  4. Jan 20

    Participants instead maintained overall positive moods (ie afterglow) in the week after dosing as well as showed improvements in sleep quality at our long-term follow-up.

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  5. Jan 20

    Our results support this, as when MDMA was given in a clinical context, where drug purity was controlled and patients could get adequate sleep and nutrition, there was no evidence of impaired mood after dosing.

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  6. Jan 20

    Therefore, it may be these factors that account for "Blue Mondays" seen in ravers rather than MDMA itself.

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  7. Jan 20

    However, there are many confounds with this research: when taken illicitly, "MDMA" is often cut with other substances, combined with alcohol and other drugs by the user, and taken in nightlife settings, where there can be concomitant dehydration, overheating, and lack of sleep

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  8. Jan 20

    To begin, post-acute affect drop (ie "Blue Monday") has been commonly documented with MDMA users (see: ), and this has been raised as a limitation to the drug's clinical use

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  9. Jan 20

    Does MDMA actually lead to mood drop in the days after dosing? Our new study in Journal of Psychopharmacology with clinically administered MDMA suggests this may be a myth 🧵👇

    18 replies 42 retweets 176 likes
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  10. Retweeted
    Jan 15

    As clinicians attempt to integrate psychedelic therapy into Western medicine, being able to predict how a person reacts to a psychedelic trip is a principal aim that can reduce harm in the long run.

    1 reply 4 retweets 14 likes
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  11. Retweeted
    Jan 15

    The deadline for our 2-5 year postdoc studying cannabinoids in the brain and body is this Monday! Last chance to join the group for a while.

    Just two weeks left to apply for our postdoc on cannabinoids, interoception, and computational psychiatry! Deadline January 17th - please let me know if you have any questions about the position!
    26 retweets 26 likes
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  12. Jan 14

    How’d I forget to mention escaping prison by hacking the personality test they used because he had designed it

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  13. Jan 14

    More crazy Leary stories are welcome below

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  14. Jan 14

    and having John Lennon write the Beatles’ “Come Together” for his campaign, being deemed the most dangerous man in America by the president. Meetings with Huxley, Warhol. I’m sure that’s just scratching the surface, but I’d watch that movie.

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  15. Jan 14

    It’s been a while since I’ve refreshed on his bio, but going from renowned Harvard professor to being sacked, getting sentenced to 30 years in prison for a minuscule amount of cannabis, to running for governor of California

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  16. Jan 14

    I feel like a biopic or even series on Timothy Leary would kill—his life story is insane

    16 replies 5 retweets 69 likes
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  17. Retweeted
    Jan 5

    SAP observations & thoughts: Health Canada is now expecting a spike in the volume of SAP requests (smart given waitlist for s56 exemptions). 392 unique respondents (25 orgs, 1 supported by 922 individuals) to original notice. <2% of all responses were opposed to amendments. 1/

    2 replies 7 retweets 19 likes
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  18. Jan 5

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  19. Jan 5

    Also, these important pieces that came out last year on the topic:

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  20. Jan 5

    We at agree—you shouldn't be able to say a study was "double-blind" or "placebo-controlled" without testing such claims. This is actually a pervasive problem across areas of clinical research, not just with psychedelics! See our review:

    I hope this will be the last "placebo-controlled" trial publication to be accepted without measuring and adequately reporting . It's time for expanded discussions about this approach, its epistemic assumptions and far reaching consequences.
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