Itai Yanai

@ItaiYanai

Author, researcher, and teacher. Ever humbled by the society of genes that built us and ever scheming to override them.

NYU, School of Medicine
Vrijeme pridruživanja: siječanj 2015.

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  1. Prikvačeni tweet
    21. stu 2019.

    Come join our lab if you’re interested in integrating spatial transcriptomics and single-cell RNA-Seq for cancer research! Postdocs and programmers especially welcome!

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  2. 27. sij

    It took and I nearly two years to publish this paper on 'transcriptional scanning' in the testes ! Luckily it was posted right away on Biorxiv!

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  3. 25. sij

    Collectively, we propose that transcriptional scanning shapes germline mutations and modulates mutation rates in a gene-specific manner, maintaining DNA sequence integrity for the bulk of genes but allowing for faster evolution in a specific subset.

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  4. 25. sij

    You might then ask, ‘why are not 100% of the genes expressed, instead of just 90%?’. When we studied this small group of unexpressed genes we found that it is enriched for sensory and immune/defense system genes. These functions are known to have evolved fast in the human lineage

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  5. 25. sij

    Moreover, this effect is fine-tuned by the level of gene expression during spermatogenesis.

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  6. 25. sij

    We found that genes expressed during spermatogenesis display lower mutation rates on the transcribed strand. In other words, the widespread gene expression in the male testes may function exclusively to correct mutations by a process we termed ‘transcriptional scanning’.

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  7. 25. sij

    But studying the results we were surprised by the exact opposite of the predicted result: genes expressed during spermatogenesis have not more but in fact fewer mutations than those that are unexpressed. We then realized that transcription-coupled repair (TCR) could be at play.

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  8. 25. sij

    Bo and I came up with the crazy hypothesis that this expression may have evolved to systematically insert mutations into the population, to increase genetic variation for evolution. We decided to test this idea by cross-referencing with DNA variations in the population.

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  9. 25. sij

    As a spermatocyte is differentiating it expresses over 90% of its genes! This seemed so strange to us, particularly since transcription can lead to DNA damage and much of the expression comes when the cell is haploid, i.e. no back-up and going into the next generation.

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  10. 25. sij

    We started with single-cell RNA-Seq on human and mouse testes, which revealed that the previously reported widespread expression in this tissue indeed comes from the germ cells and not the soma cells.

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  11. 25. sij

    Following a few requests, here’s the (now-required) Twitter summary of our paper on 'transcriptional scanning' in the testes.

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  12. 25. sij

    Thank you Bluma Lesch for the Cell Preview about our work on transcriptional scanning in the testes! (unfortunately you are not on Twitter!)

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  13. proslijedio/la je Tweet
    23. sij

    Very excited to share our latest work published on ! With , we address long-standing mystery that testis has the most widespread transcriptome. We proposed that ‘transcriptional scanning’ modulates gene mutation rates, and ultimately gene evolution rates!

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  14. proslijedio/la je Tweet
    23. sij

    and colleagues investigate why the expresses the largest number of genes of any mammalian organ. Read the paper @ . Cover art inspired by this study is from of STAT News

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  15. 23. sij

    Thank you! Bo Xia did an absolutely spectacular job in this project!

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  16. 23. sij

    Sperm cells express nearly all genes - a well-known yet mysterious observation. In our new paper, we hypothesize ‘transcriptional scanning’ where expression is coupled globally for DNA repair and even modulates gene evolution rates.

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  17. proslijedio/la je Tweet
    21. sij

    For all of you who are trying to find a project, a question, or just find your way in science. Check out this very interesting and relevant piece by and Martin Lercher. Definitely worth reading, especially at night :P

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  18. proslijedio/la je Tweet
    16. sij

    Took me a year to adjust to uni academics and, as a RA for freshmen, I know this is common. We need to stop viewing intro classes as “weed outs” & instead help w/ transition to pre-med classes. Glad research like this shows the importance of improvement vs perfect performance

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  19. 16. sij

    This work was led by Tal Baron in my lab, and it was a great collaboration with my colleagues Robert Grossman, Steven Abramson, Martin Pusic, Rafael Rivera, and Marc Triola.

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  20. 16. sij

    Our big data approach presented here can more sensitively uncover success potential since it takes into account the inherent heterogeneity within the student population.

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  21. 16. sij

    Finally, we demonstrate that when taking signatures into account, prediction of success is improved.

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