Tweetovi
- Tweetovi, trenutna stranica.
- Tweetovi i odgovori
- Medijski sadržaj
Blokirali ste korisnika/cu @ItaiYanai
Jeste li sigurni da želite vidjeti te tweetove? Time nećete deblokirati korisnika/cu @ItaiYanai
-
Prikvačeni tweet
Come join our lab if you’re interested in integrating spatial transcriptomics and single-cell RNA-Seq for cancer research! Postdocs and programmers especially welcome!
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
It took
@boxia7 and I nearly two years to publish this paper on 'transcriptional scanning' in the testes https://www.cell.com/cell/fulltext/S0092-8674(19)31377-7 …! Luckily it was posted right away on Biorxiv!https://twitter.com/ItaiYanai/status/974080193139748865 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Collectively, we propose that transcriptional scanning shapes germline mutations and modulates mutation rates in a gene-specific manner, maintaining DNA sequence integrity for the bulk of genes but allowing for faster evolution in a specific subset.pic.twitter.com/icZZaiuqtb
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
You might then ask, ‘why are not 100% of the genes expressed, instead of just 90%?’. When we studied this small group of unexpressed genes we found that it is enriched for sensory and immune/defense system genes. These functions are known to have evolved fast in the human lineagepic.twitter.com/fXLyHxKVvn
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Moreover, this effect is fine-tuned by the level of gene expression during spermatogenesis.pic.twitter.com/E39HfJKPKr
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
We found that genes expressed during spermatogenesis display lower mutation rates on the transcribed strand. In other words, the widespread gene expression in the male testes may function exclusively to correct mutations by a process we termed ‘transcriptional scanning’.pic.twitter.com/skrQs9f11o
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
But studying the results we were surprised by the exact opposite of the predicted result: genes expressed during spermatogenesis have not more but in fact fewer mutations than those that are unexpressed. We then realized that transcription-coupled repair (TCR) could be at play.pic.twitter.com/7pNrqMCzsm
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Bo and I came up with the crazy hypothesis that this expression may have evolved to systematically insert mutations into the population, to increase genetic variation for evolution. We decided to test this idea by cross-referencing with DNA variations in the population.
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
As a spermatocyte is differentiating it expresses over 90% of its genes! This seemed so strange to us, particularly since transcription can lead to DNA damage and much of the expression comes when the cell is haploid, i.e. no back-up and going into the next generation.pic.twitter.com/3N8vlkSqRy
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
We started with single-cell RNA-Seq on human and mouse testes, which revealed that the previously reported widespread expression in this tissue indeed comes from the germ cells and not the soma cells.pic.twitter.com/J2JijzGRNE
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Following a few requests, here’s the (now-required) Twitter summary of our paper on 'transcriptional scanning' in the testes.
@BoXia7 https://www.cell.com/cell/fulltext/S0092-8674(19)31377-7 …pic.twitter.com/GAI48Dh10K
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Thank you Bluma Lesch for the Cell Preview about our work on transcriptional scanning in the testes! https://www.cell.com/cell/fulltext/S0092-8674(19)31395-9 … (unfortunately you are not on Twitter!)
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Itai Yanai proslijedio/la je Tweet
Very excited to share our latest work published on
@CellCellPress! With@ItaiYanai, we address long-standing mystery that testis has the most widespread transcriptome. We proposed that ‘transcriptional scanning’ modulates gene mutation rates, and ultimately gene evolution rates! https://twitter.com/CellCellPress/status/1220390305716981762 …pic.twitter.com/5pyxL190X8
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Itai Yanai proslijedio/la je Tweet
@ItaiYanai and colleagues investigate why the#testis expresses the largest number of genes of any mammalian organ. Read the paper @ http://bit.ly/2RHrFGQ . Cover art inspired by this study is from@MollyFerg_Art of STAT News#scubadivingpic.twitter.com/hH7jbi7ad8
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Thank you! Bo Xia
@BoXia7 did an absolutely spectacular job in this project!Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Sperm cells express nearly all genes - a well-known yet mysterious observation. In our new paper, we hypothesize ‘transcriptional scanning’ where expression is coupled globally for DNA repair and even modulates gene evolution rates.
@boxiahttps://www.cell.com/cell/fulltext/S0092-8674(19)31377-7 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Itai Yanai proslijedio/la je Tweet
For all of you who are trying to find a project, a question, or just find your way in science. Check out this very interesting and relevant piece by
@ItaiYanai and Martin Lercher. Definitely worth reading, especially at night :Phttps://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1902-1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Itai Yanai proslijedio/la je Tweet
Took me a year to adjust to uni academics and, as a RA for freshmen, I know this is common. We need to stop viewing intro classes as “weed outs” & instead help w/ transition to pre-med classes. Glad research like this shows the importance of improvement vs perfect performancehttps://twitter.com/ItaiYanai/status/1217866596309458946 …
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
This work was led by Tal Baron in my lab, and it was a great collaboration with my
#NYULangone colleagues Robert Grossman, Steven Abramson, Martin Pusic, Rafael Rivera, and Marc Triola.@nyumedcomputePrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Our big data approach presented here can more sensitively uncover success potential since it takes into account the inherent heterogeneity within the student population.
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Finally, we demonstrate that when taking signatures into account, prediction of success is improved.pic.twitter.com/dFnpOo6OES
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
Čini se da učitavanje traje već neko vrijeme.
Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.