Mice
are excellent decision-makers, and can learn to perform complicated tasks. So far, such behavior often relied on custom-built setups, and required the 'artist's hands' of experienced mouse whisperers. 2/10pic.twitter.com/3szADKLeK6
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However, to study the neural basis of decision-making, we need reliable paradigms for mouse behavior! Our team established standardized methods to ensure the
#reproducibility of mouse behavior across different labs. 3/10Prikaži ovu nit -
After teaching 101 mice the same behavioral task, we asked if their behavior was really reproducible across labs. A trained classifier was not able to tell which lab each mouse came from. We've never been so happy to see a classifier fail! 4/10pic.twitter.com/rjGNi4xgK4
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We also trained mice on a variant of the task, where they integrate priors into their decision strategy. Across different labs, mice use this information in a similar way. 5/10pic.twitter.com/Ghy1ITnx79
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In the process, we developed a ton of resources that we'd love the community to use. In the Appendix you'll find guides to surgery https://doi.org/10.6084/m9.figshare.11634726 … and mouse training https://doi.org/10.6084/m9.figshare.11634729 …
#openscience 6/10Prikaži ovu nit -
With
@SanworksLLC, we've designed easy-to-build rigs that you can put together from off-the-shelf, open-source parts and some 3D printed components. At#SfN19, we built it in 1 day! Parts list and instructions: https://doi.org/10.6084/m9.figshare.11634732 … 7/10pic.twitter.com/clG33XGRpHPrikaži ovu nit -
We’ve also figured out how to work together in large, distributed groups. Our team is in 22 labs, across 15 research institutes - with 9 hours time difference
#teamscience 8/10pic.twitter.com/pPNEpP10KG
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Of course, the code https://github.com/int-brain-lab/paper-behavior … and data https://data.internationalbrainlab.org/ are all open. Huge thanks to
@DataJointNeuro for the beautiful interactive visualizations. 9/10pic.twitter.com/vBLorf3uLB
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We're now using these methods and infrastructure to record brain activity while mice perform this decision-making task. Watch this space for spikes!

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And of course, none of this would have been possible without the support of
@wellcometrust and@SCglobalbrain.pic.twitter.com/Sm4XaxUGdjPrikaži ovu nit
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