International Brain Laboratory

@IntlBrainLab

Experimental & theoretical neuroscientists collaborating to understand brainwide circuits for complex behavior

Vrijeme pridruživanja: studeni 2016.

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  1. Prikvačeni tweet

    After >2 years of effort by our team in 7 labs, we present to you: 3 million choices from 101 mice in a standardized decision-making task. 🐭 "A standardized and reproducible method to measure decision-making in mice" Story time! 🧵👇 1/10

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  2. International Brain Initiative: An Innovative Framework for Coordinated Global Brain Research Efforts

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  3. proslijedio/la je Tweet
    28. sij
    Odgovor korisniku/ci

    I'm with you!! The multi lab aspect is really important. There are lots of problems to solve that are beyond the scale of a single lab.

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  4. proslijedio/la je Tweet
    25. sij

    Check this out if you are interested in super reproducible head fixation across days or different rigs! Very helpful for accurately targeting the same 2P FOV repeatedly in multiple sessions.

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  5. proslijedio/la je Tweet
    23. sij

    Google Dataset Search is now officially out of beta. "Dataset Search has indexed almost 25 million of these datasets, giving you a single place to search for datasets & find links to where the data is." Nice work, Natasha Noy and everyone else involved!

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  6. And of course, none of this would have been possible without the support of and .

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  7. We're now using these methods and infrastructure to record brain activity while mice perform this decision-making task. Watch this space for spikes! 🧠⚡️ 10/10

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  8. Of course, the code and data are all open. Huge thanks to for the beautiful interactive visualizations. 9/10

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  9. We’ve also figured out how to work together in large, distributed groups. Our team is in 22 labs, across 15 research institutes - with 9 hours time difference 🕑 8/10

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  10. With , we've designed easy-to-build rigs that you can put together from off-the-shelf, open-source parts and some 3D printed components. At , we built it in 1 day! Parts list and instructions: 7/10

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  11. In the process, we developed a ton of resources that we'd love the community to use. In the Appendix you'll find guides to surgery and mouse training 6/10

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  12. We also trained mice on a variant of the task, where they integrate priors into their decision strategy. Across different labs, mice use this information in a similar way. 5/10

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  13. After teaching 101 mice the same behavioral task, we asked if their behavior was really reproducible across labs. A trained classifier was not able to tell which lab each mouse came from. We've never been so happy to see a classifier fail! 4/10

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  14. However, to study the neural basis of decision-making, we need reliable paradigms for mouse behavior! Our team established standardized methods to ensure the of mouse behavior across different labs. 3/10

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  15. Mice 🐭 are excellent decision-makers, and can learn to perform complicated tasks. So far, such behavior often relied on custom-built setups, and required the 'artist's hands' of experienced mouse whisperers. 2/10

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  16. proslijedio/la je Tweet
    16. sij

    Science twitter, pls advise: Suppose some authors include a statement w/ their paper that data is available upon request. If one makes such a request, how soon might one expect some sort of response? What does one do if no response?

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  17. proslijedio/la je Tweet
    14. sij

    The is hiring software engineers and neuroscience postdocs. Apply and join an exciting large-scale international scientific collaboration in brain research. Please retweet!

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  18. Start your week by checking out this nice piece on team science, featuring Happy Monday!

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  19. As we're preparing our first publications, we'd like to get an ID for the as a whole. Is this allowed/possible as a consortium?

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  20. proslijedio/la je Tweet
    30. pro 2019.

    My dept seminar series is going CO2 free! It's easy to set up and it works, including one on one meetings. If you want to try it in your dept, you can find all the details at under the 'technologies' tab

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