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  1. Prikvačeni tweet
    prije 7 sati

    How can we advance the development of immunotherapies? In this perspective we outline how single-cell genomics can revolutionize drug development. By together with now . (1/6)

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    Another approach relies on mathematical modeling for combos that address the interactions (since they're so simple, Figure😉) and the goal of modulating tumor perfusion. by

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    prije 3 sata

    They didn’t tell me that this was part of the deal but it was worth it just to thank the organizers

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    prije 3 sata

    dishes will not be washed by ordinary guys!

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  5. proslijedio/la je Tweet
    prije 10 sati

    Our review on inflammatory memory in barrier tissues with now out in !

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    Single-cell genomic approaches for developing the next generation of immunotherapies | Nature Medicine

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    Perspective on single-cell genomic approaches for developing the next generation of immunotherapies by .

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    A new paper from the Spitale lab shows how mammalian cells salvage pyrimidine analogs, and describes new enzyme-small molecule pair for cell-type specific metabolic labeling of RNA

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    Immunotherapy for needs refinement and this perspective makes a solid case that single-cell can help us get there by

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    A new perspective by , and on how single cell can revolutionize is available online today. Read here:

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    : new protocol allows to preserve RNA+protein and can be combined with intracellular protein detection. Combine with CITE-seq and think about signaling, phosphoflow, transcription factors you will be able to measure! Will be a game-changer for multi-omics!

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  12. proslijedio/la je Tweet
    prije 7 sati

    Could single-cell genomic technologies hold the key to develop the next generation of ?

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  13. prije 7 sati

    In summary, we anticipate that single-cell technologies will become an essential tool for drug development in the near future, and will drive a revolution in the research and development of immunotherapies. (6/6)

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  14. prije 7 sati

    In the perspective we outline how single-cell analysis can be used to select a mouse/organoid model system, direct antibody-engineering approaches, and compare between mono- and combination-therapy, facilitating rational design of the most effective treatment courses. (5/6)

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  15. prije 7 sati

    Evaluating the function of immunotherapies by simple parameters, like tumor growth or cell type measurements, limits our ability to outline their precise mechanisms of action. resolves this, by defining the cells and pathways affected by the treatment. (4/6)

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  16. prije 7 sati

    Tumors contain a mixture of cells of different lineages and states, participating in pro/anti-tumor activities. While immunotherapies have a specific target (e.g. PD-1), they may cause diverse direct and secondary effects, leading to the anticipated response, or lack of it. (3/6)

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  17. prije 7 sati

    Our vision is that in the coming years single-cell analysis will be fully integrated in drug development pipelines, empowering the discovery of new targets and biomarkers, enabling definition of immunotherapies’ mechanisms of action, guiding the design of clinical trials. (2/6)

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    2. velj
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    prije 9 sati

    Indeed, awesome projects & talk!! I may be biased though...😉

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  20. proslijedio/la je Tweet

    at new studies on iPSC-derived resident macrophages in 3D organoids: beautiful live imaging in the organoids!!! What a mindblowing day !

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