World War I and all the horrors of the 20th century started right after governments started banning the popular Bayer cough suppressant "Heroin".
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One of my worst days in high school was when a friend of mine overdosed on quaaludes and cheap liquor and we had to keep her walking or she was going to die. She finally agreed to go into school and tell the office she needed help.
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I'd throw in the rise of Gingrich Republicans being due to the downfall of Pablo Escobar.
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