Enough selection can take care of the downsides https://twitter.com/clairlemon/status/926746754455822338 …
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Many tribal societies dealt with it by practicing exogamy.
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One thing often missed re inbreeding: in animal breeding, it's often used to expose bad alleles to allow selection against them. More exogamy doesn't get rid of the bad stuff as well, just spreads it around more
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