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Fibrinogen and fibrin are implicated in different disorders. Which are the mechanisms that may contribute to disease? https://buff.ly/2SjjNvl pic.twitter.com/7pCErPh8Nb
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February issue is available online. See and download for free the Haematologica Digital Edition! https://buff.ly/3b4tPtd pic.twitter.com/77cjMzKNEi
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The demographic and clinical characteristics of extramedullary disease (extramedullary plasmacytoma or paraosseous involvement) among 226 myeloma patients at initial diagnosis or relapse and its impact on treatment outcomes. https://buff.ly/2sLnp0q pic.twitter.com/jKZfabN2zu
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In order to clarify the role of new drugs in MM with extra-medullary disease, Montefusco et al. conducted the largest meta-analysis so far reported, based on eight prospective trials by the same sponsors. https://buff.ly/2SNx4yg pic.twitter.com/NXwmLr3CSw
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The strong and selective anti-leukemia activity of APR-246 in TP53-mutated ALL provides the basis to develop personalized therapy regimens for this high-risk subgroup of ALL. https://buff.ly/39zb3JB pic.twitter.com/RyZwpfzIi4
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Smog e Malattie cardiovascolari Il particolato, in particolare quello più fine, causa tumori, patologie respiratorie e soprattutto cardiovascolari. E i limiti Ue sono ancora troppo elevati. L'allarme dei ricercatori italiani: più infarti e ictus https://buff.ly/2RB3gCJ pic.twitter.com/Bykw4fO6GL
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These data expand our understanding of the potential mechanisms initiating enhanced IL-6 production in mastocytosis and emphasize targets for therapeutic intervention in cases of high IL-6 profiles and suspected disease progression. https://buff.ly/37y4xRC pic.twitter.com/UuJy0Yhy5z
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Homoharringtonine (HHT) - a cytotoxic alkaloid approved by the US FDA for treatment of CML – for the treatment of AML carrying FLT3 mutations and/or with overexpression of endogenous TET1/FLT3/HOXA9/MEIS1. https://buff.ly/2ZOL6kx pic.twitter.com/MFECDUkD3j
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These data demonstrate the BCR-ABL1-specific, cell-intrinsic pathways leading to altered interactions with the vascular niche via the modulation of adhesion molecules – which could be exploited therapeutically in the future. https://buff.ly/37oCAeS pic.twitter.com/z5tYzlNHoX
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Available evidence on the use of donor lymphocyte infusion from haploidentical donor, and recommendations on its therapeutic, pre-emptive and prophylactic use in clinical practice. https://buff.ly/2SQeGVs pic.twitter.com/cw2Xr630ql
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Research on intrinsic mechanisms responsible for HSC aging is providing, and will continue to provide, new potential molecular targets to possibly ameliorate or delay aging of the hematopoietic system. https://buff.ly/2MQEKff pic.twitter.com/znARoAzGUx
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The crosstalk between hematopoietic stem cells and the microenvironment is indispensable for the aging of the hematopoietic system and might represent a therapeutic target in age-related pathological disorders. https://buff.ly/2rPnVKu pic.twitter.com/Ig6NNRogak
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January issue is available online. See and download for free the Haematologica Digital Edition! https://buff.ly/2PZBYXe pic.twitter.com/8rY9TLqdso
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Preferential pro-apoptotic responses of CLL cells to a second-generation and clinically relevant MDM2 inhibitor (RG7388) exposure, compared with those of normal hematopoietic cells. https://buff.ly/2rPa0Ux pic.twitter.com/uIvN5o0jv4
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Perturbations in DNA damage response pathways in FLT3-ITD AML could be harnessed to provide novel strategies for the treatment of this aggressive neoplasm.https://buff.ly/382TwIQ
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Potentially pathogenic somatic variants of epigenetic modifiers are common in CML-CP at diagnosis, and when combined with other risk factors may be promising predictive biomarkers determining which is the best TKI for each individual.https://buff.ly/2OLX0aY
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An Atlas of Hematology celebrates the Centenary of the free scientific journal, Haematologica. It had 9 million visitors to its website just in 2018. Haematologica is an Open Access journal that aims to promote research into blood diseases and treatments. http://buff.ly/36Q4O1V pic.twitter.com/AW6x4JtJbJ
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The results of this study establish the MBD2 Nucleosome Remodeling and Deacetylase complex as a major silencer of fetal hemoglobin in human erythroid cells https://buff.ly/2ReBTjj pic.twitter.com/b8wRDTA9Iu
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This manuscript proposes practical considerations for the use of CAR-T cell therapy in Multiple Myeloma, and discusses several important issues for its future development. https://buff.ly/34NfMVk pic.twitter.com/qmxm2477uF
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The global mortality and morbidity burden of cardiovascular disease associated with air pollution, particularly for the PM2.5 size fraction, is dramatically greater than what has been thought up to now. https://buff.ly/35UZycK pic.twitter.com/OY0McBxvPQ
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