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HCCvPDAC's profile
Howard Crawford
Howard Crawford
Howard Crawford
@HCCvPDAC

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Howard Crawford

@HCCvPDAC

I research and I know things. Pancreatic cancer can get bent! Views expressed not attributable to my employer (except the one about trying to eradicate PDAC)

Ann Arbor, MI
Joined November 2017

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    1. Howard Crawford‏ @HCCvPDAC Aug 15

      Ok, I brush myself off and rework the grant again. It goes to a Special Emphasis Panel (for the youngsters- a study section for PIs that are in conflict with standing study sections, usually because they’re a member). /21

      1 reply 0 retweets 23 likes
      Show this thread
    2. Howard Crawford‏ @HCCvPDAC Aug 15

      12%. Sigh. /22

      1 reply 0 retweets 15 likes
      Show this thread
    3. Howard Crawford‏ @HCCvPDAC Aug 15

      Now we’re at the point we need to publish not just the preliminary data, but the results of some the experiments we proposed (Where did *that* money come from?). Which, if you do, you’ve scooped yourself and you have to come up with a whole new plan!/23

      1 reply 1 retweet 46 likes
      Show this thread
    4. Howard Crawford‏ @HCCvPDAC Aug 15

      Don’t forget, the self-scoop is be made up entirely of data that the NCI wouldn't fund. And with a new plan, you’ve got to have new prelim data *and* convince a study section that the next steps are just as important as the ones they refused to support the first few times./24

      1 reply 2 retweets 33 likes
      Show this thread
    5. Howard Crawford‏ @HCCvPDAC Aug 15

      What are the critiques? Most were cool and super complimentary./25

      1 reply 0 retweets 14 likes
      Show this thread
    6. Howard Crawford‏ @HCCvPDAC Aug 15

      One reviewer clearly doesn’t believe in cellular plasticity so trashes one of the aims, calling it “farfetched”. (Oooh, but of course in the past couple of months we’ve finished that aim and it’s even cooler than we could have hoped. BTW, where did *that* money come from?). /26

      2 replies 0 retweets 38 likes
      Show this thread
    7. Howard Crawford‏ @HCCvPDAC Aug 15

      Oh, yes… and the proposal is not translational enough. /27

      1 reply 0 retweets 17 likes
      Show this thread
    8. Howard Crawford‏ @HCCvPDAC Aug 15

      Another reviewer clearly thought that reviewer was insane and had nothing but nice things to say. These reviewers ARE out there, people! Marry them if you have to. No wait, then they’d be COI. Don’t marry them./28

      2 replies 3 retweets 102 likes
      Show this thread
    9. Howard Crawford‏ @HCCvPDAC Aug 15

      The last reviewer was nice, if a little wishy washy. They criticized 1 aim pretty harshly because I didn’t have the 6 allele mouse I needed in hand. NOT that the alleles haven’t been *created* yet. Just that they have not been BRED together yet. If only @DrBenNeel were there!/29

      2 replies 0 retweets 20 likes
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    10. Howard Crawford‏ @HCCvPDAC Aug 15

      Oh and show data from those mice. In other words, “finish the aim, then we’ll talk.”/30

      1 reply 0 retweets 37 likes
      Show this thread
      Howard Crawford‏ @HCCvPDAC Aug 15

      BTW, this was the reviewer that said I didn’t address sex as a biological variable when there was an entire paragraph about it. FYI, I underlined that paragraph without explanation in the resubmission because... I’m the devil./31

      12:07 PM - 15 Aug 2019
      • 1 Retweet
      • 52 Likes
      • James West Ligand-Gated Vibranium Ion Channel Jen O'Keefe David Coleman Liz Haynes 🐟🔬 Emily Manoogian I collect spores, molds, and fungi Noah Jones Wonmo Sung
      3 replies 1 retweet 52 likes
        1. New conversation
        2. Howard Crawford‏ @HCCvPDAC Aug 15

          Cool new data added. Even preliminary data for “where’s your 6 allele mouse model” reviewer. I should be confident, right? So why not? Because there’s only a negligible chance the A1 will see any of the same reviewers. /32

          1 reply 0 retweets 17 likes
          Show this thread
        3. Howard Crawford‏ @HCCvPDAC Aug 15

          Mo reviewers, mo problems. I know. I’ve been there. As a reviewer, I sweat bullets when I read the Intro and see they’ve been very responsive, but the advice was… just bad./33

          1 reply 1 retweet 26 likes
          Show this thread
        4. Howard Crawford‏ @HCCvPDAC Aug 15

          Then I read the grant and see fundamental mistakes that I can’t ignore. I totally forgive cases where I simply have a different opinion. If you’re responsive and there’s not fatal flaw, you’re golden with me. /34

          1 reply 2 retweets 28 likes
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        5. Howard Crawford‏ @HCCvPDAC Aug 15

          I hate to tell you this young ‘uns, but that’s really not the norm. And all it takes is one reviewer./35

          2 replies 1 retweet 32 likes
          Show this thread
        6. Howard Crawford‏ @HCCvPDAC Aug 15

          And therein lies the problem. With an 8% pay line, all it takes is one reviewer. One reviewer who doesn’t have the right knowledge base. One reviewer who simply isn’t excited about your proposal. One reviewer who says “it’s not translational enough”. /36

          5 replies 23 retweets 143 likes
          Show this thread
        7. Howard Crawford‏ @HCCvPDAC Aug 15

          One reviewer who had to comment on 10 other grants. One reviewer who was taking care of a sick kid and missed some major points./37

          2 replies 0 retweets 37 likes
          Show this thread
        8. Howard Crawford‏ @HCCvPDAC Aug 15

          A stressed reviewer in a room full of stressed reviewers. Panel members who feel like they don’t have the expertise to make an informed decision, so they vote down the middle, with boundaries set in part by that one reviewer. That’s all it takes./38

          1 reply 4 retweets 55 likes
          Show this thread
        9. Howard Crawford‏ @HCCvPDAC Aug 15

          By the time you’ve got your reviews, it will likely be the better part of a year before you can resubmit. And wait. And hope you won the reviewer lottery. At least this time. Did I say "lottery"?/39

          1 reply 0 retweets 32 likes
          Show this thread
        10. Howard Crawford‏ @HCCvPDAC Aug 15

          Is the system broken? You know the answer to that./40

          1 reply 1 retweet 27 likes
          Show this thread
        11. Howard Crawford‏ @HCCvPDAC Aug 15

          End rant. I'd say "Thanks for coming to my Ted Talk" but I'm pretty sure Ted Talks are shorter./end

          8 replies 0 retweets 45 likes
          Show this thread
        12. Howard Crawford‏ @HCCvPDAC Aug 15

          I failed to mention that I didn’t bother to resubmit. Waste of time. Went to a new A0, which got the 12%

          2 replies 0 retweets 25 likes
          Show this thread
        13. Howard Crawford‏ @HCCvPDAC Aug 15

          Ack, I didn’t resubmit the *ND*! All others are worth resubmitting

          4 replies 0 retweets 24 likes
          Show this thread
        14. End of conversation
        1. New conversation
        2. barvasfiend‏ @barvasfiend Aug 18
          Replying to @HCCvPDAC

          Had that happen too. Asked to address something that was already in the proposal. Tricky, cos I didn't want to point out the reviewer just hadn't read the thing properly.

          1 reply 0 retweets 0 likes
        3. Howard Crawford‏ @HCCvPDAC 24h24 hours ago
          Replying to @barvasfiend

          “We appreciate the we were not clear on this point in our previous application. This information can now be found on page x” and don’t change a thing

          0 replies 0 retweets 0 likes
        4. End of conversation
        1. New conversation
        2. Rejji Kuruvilla‏ @rkuruvi1 Aug 15
          Replying to @HCCvPDAC

          Painful thread that many of us have been through. 12% would have been funded at any other NIH institute, indicating that it’s not largely the reviewers, but an institute that sets one up to fail at 8%?

          1 reply 0 retweets 1 like
        3. Francesca Cole‏ @ColeFrancesca Aug 16
          Replying to @rkuruvi1 @HCCvPDAC

          Not NICHD (9th percentile) 😭

          1 reply 0 retweets 0 likes
        4. Rejji Kuruvilla‏ @rkuruvi1 Aug 16
          Replying to @ColeFrancesca @HCCvPDAC

          Wow! Thought NCI was the only one

          0 replies 0 retweets 0 likes
        5. End of conversation

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