Comments welcome. I've expanded it since the blog post. The biggest addition is a section on stratification, as the blog post was written before the issues with the height polygenic scores were found.
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Polygenic scores provide a remarkable tool for understanding complex traits in diverse areas of human genetics. But they have a lot of limitations as well. It's only by fully acknowledging those issues that we can move forward.
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For example, I remain excited about using PGS to understand selection on complex traits such as height. But even there there is a big gulf between saying that height PGS differ among groups and saying we know the contribution of genetics to height differences.
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TeaWAS
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Fun fact: my mum is in the UK biobank and was confused by the 'how many cups of tea do you drink' question (thinking of the measurement, but didn't know how much it was). She ended up putting *10* cups of tea per day (true phenotype: 3-5 mugs)
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Soon in headlines: Consumer Genetic Testing Company quietly ends their million dollar partnership with Yorkshire to use your genetic data to predict whether you'd like regular, Gold, Biscuit Brew, or decaf best.
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a few months later: we interviewed this farmer and it turns out that regular, Gold, Biscuit Brew, and decaf are all the same.
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Excellent to see this expanded and put out there!
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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I would be interested in your comments on this new paper which discusses multiple approaches to cross-group comparisons. I have no connection whatsoever to the paper or authors - just interested in your view on it.https://www.mdpi.com/2624-8611/1/1/34 …
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title makes me think of this masterpiece by
@DanGraur: "reading the entrails of chickens: molecular timescales of evolution and the illusion of precision" https://ncbi.nlm.nih.gov/pubmed/14746989Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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