Science people! I want to know about MTHFR mutations, who can tell me all about them? RT until someone knows!
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Most of the described variants are associated with elevated homocysteine. Big debates about whether lowering with b vitamin supplementation is beneficial . Most meta analyses are null but recently reinvigorated by recent CSPPT
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CSPPT randomized to folic acid, was unique for a number of reasons; only Hcy lowering trial with stroke as primary outcome, and done in China where there's no mandaotey folic acid fortification of food supply so lower background Intake
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