Acid blockers, statins, narcotics for chronic pain, just to name a fewhttps://twitter.com/gidmk/status/798644709384077313 …
These medications have many known effects and side-effects on 100s of different systems, they are staggeringly complex.
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And as for adaptivity, we know that the body DOES adapt to the use of opiods, which is why long-term use isn't great
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