Best evidence indicates few harms, so it's spurious to ascribe a plethora of problems to HPV vax. https://twitter.com/itsmepanda1/status/747775703920279553 …
The idea is that certain types of evidence carry more weight, due to a number of factors like size, control, reliability etc.
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Generally speaking, systematic reviews are the 'top' form of evidence, then RCTs, case-control/cohort, lab-bench, anecdotal.
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Each 'tier' generally provides stronger evidence than the one below; it's simplified but still a decent guide.
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