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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Sep 18

      See, thing is, most of the studies that supported the idea that there is a large benefit for ivermectin appear to be either fraudulent or so poorly conducted that they might as well be fakepic.twitter.com/OQvRFR38tC

      4 replies 16 retweets 170 likes
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    2. Health Nerd‏Verified account @GidMK Sep 18

      On the other hand, the only large, well conducted trials seem to find either no benefit or at best quite a modest one

      2 replies 4 retweets 119 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Sep 18

      Indeed, if you remove just two trials from your analysis - Elgazzar and Niaee - there is not a single RCT that has found a benefit for mortality, and on aggregate the result is pretty solidly 🤷‍♂️🤷‍♂️

      5 replies 5 retweets 137 likes
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    4. Health Nerd‏Verified account @GidMK Sep 18

      What then separates ivermectin from other repurposed drugs? Popularity?pic.twitter.com/aKSrYM3CfG

      4 replies 4 retweets 80 likes
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    5. Health Nerd‏Verified account @GidMK Sep 18

      Anyway, this doesn't mean that we should stop the ongoing large trials into ivermectin, but I do think it's an interesting point worth considering. Take away the fraud, rewind to the actual evidence, and what remains?

      11 replies 8 retweets 148 likes
      Show this thread
    6. Dr. Eric Osgood MD‏ @EdoajoEric Sep 18
      Replying to @GidMK

      In terms of trials that are well-designed, non-fraudulent, powered enough to show important outcomes, peer reviewed and published? Vallejos and Mahmud.

      1 reply 0 retweets 4 likes
    7. Dr. Eric Osgood MD‏ @EdoajoEric Sep 18
      Replying to @EdoajoEric @GidMK

      Vallejos N= around 250 per arm if I remember correctly, showed a 34% reduction in hospitalization that didnt reach statistical significance with 0.2mg/kg-ish x 2 doses. Mahmud N=250 per arm fixed 12mg ivm dose+doxy showed 50% less deterioration which was statistically significant

      2 replies 0 retweets 4 likes
    8. Dr. Eric Osgood MD‏ @EdoajoEric Sep 18
      Replying to @EdoajoEric @GidMK

      This is more robust evidence than that which informs about 90% of infectious disease professional guidelines.

      1 reply 0 retweets 6 likes
    9. Health Nerd‏Verified account @GidMK Sep 18
      Replying to @EdoajoEric

      That I don't really know, but I'm not sure us using bad evidence for most stuff is necessarily a good reason to use inconclusive evidence for ivermectin either

      1 reply 0 retweets 0 likes
    10. Dr. Eric Osgood MD‏ @EdoajoEric Sep 18
      Replying to @GidMK

      There are numerous reasons why infectious diseases has relied on expert opinion and observational data to inform most of its practice, primarily ethics, and feasibility. In the case of covid, neither is the case, we really should have had conclusive data by now.

      2 replies 0 retweets 4 likes
      Health Nerd‏Verified account @GidMK Sep 18
      Replying to @EdoajoEric

      But in this case it isn't really observational evidence of the quality that's incorporated into recommendations - the obs evidence is mostly not of sufficient quality to include in any recommendations either. Also, lots of fraud there too

      5:52 AM - 18 Sep 2021
      • 1 Like
      • Dr. Eric Osgood MD
      1 reply 0 retweets 1 like
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