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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Sep 18

      "There's enough behind ivermectin for COVID-19 that there must be something there" This is a point that I find fascinating 🧵

      29 replies 50 retweets 266 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Sep 18

      See, thing is, most of the studies that supported the idea that there is a large benefit for ivermectin appear to be either fraudulent or so poorly conducted that they might as well be fakepic.twitter.com/OQvRFR38tC

      4 replies 16 retweets 170 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Sep 18

      On the other hand, the only large, well conducted trials seem to find either no benefit or at best quite a modest one

      2 replies 4 retweets 119 likes
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    4. Health Nerd‏Verified account @GidMK Sep 18

      Indeed, if you remove just two trials from your analysis - Elgazzar and Niaee - there is not a single RCT that has found a benefit for mortality, and on aggregate the result is pretty solidly 🤷‍♂️🤷‍♂️

      5 replies 5 retweets 137 likes
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    5. Health Nerd‏Verified account @GidMK Sep 18

      What then separates ivermectin from other repurposed drugs? Popularity?pic.twitter.com/aKSrYM3CfG

      4 replies 4 retweets 80 likes
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    6. Health Nerd‏Verified account @GidMK Sep 18

      Anyway, this doesn't mean that we should stop the ongoing large trials into ivermectin, but I do think it's an interesting point worth considering. Take away the fraud, rewind to the actual evidence, and what remains?

      11 replies 8 retweets 148 likes
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    7. Dr. Eric Osgood MD‏ @EdoajoEric Sep 18
      Replying to @GidMK

      In terms of trials that are well-designed, non-fraudulent, powered enough to show important outcomes, peer reviewed and published? Vallejos and Mahmud.

      1 reply 0 retweets 4 likes
    8. Dr. Eric Osgood MD‏ @EdoajoEric Sep 18
      Replying to @EdoajoEric @GidMK

      Vallejos N= around 250 per arm if I remember correctly, showed a 34% reduction in hospitalization that didnt reach statistical significance with 0.2mg/kg-ish x 2 doses. Mahmud N=250 per arm fixed 12mg ivm dose+doxy showed 50% less deterioration which was statistically significant

      2 replies 0 retweets 4 likes
    9. Health Nerd‏Verified account @GidMK Sep 18
      Replying to @EdoajoEric

      Also Mohan, showing no stat sig, but benefits for placebo at day 3/10 and benefit for ivm at day 5. In Vallejos, there was a 34% reduction in hospitalization but a 33% increase in mechanical ventilation in the ivm group (both non-sig)

      2 replies 0 retweets 4 likes
      Health Nerd‏Verified account @GidMK Sep 18
      Replying to @GidMK @EdoajoEric

      Even Mahmud had some variables where placebo did better than ivm! Not a slam dunk, sure, but once you get rid of the fraud it's really inconclusive imo 🤷‍♂️

      5:09 AM - 18 Sep 2021
      • 3 Likes
      • Ariti 🤐🏁 Will Brockman Markus Plesner Dalin
      2 replies 0 retweets 3 likes
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