"There's enough behind ivermectin for COVID-19 that there must be something there"
This is a point that I find fascinating 
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See, thing is, most of the studies that supported the idea that there is a large benefit for ivermectin appear to be either fraudulent or so poorly conducted that they might as well be fakepic.twitter.com/OQvRFR38tC
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On the other hand, the only large, well conducted trials seem to find either no benefit or at best quite a modest one
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Indeed, if you remove just two trials from your analysis - Elgazzar and Niaee - there is not a single RCT that has found a benefit for mortality, and on aggregate the result is pretty solidly

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What then separates ivermectin from other repurposed drugs? Popularity?pic.twitter.com/aKSrYM3CfG
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Anyway, this doesn't mean that we should stop the ongoing large trials into ivermectin, but I do think it's an interesting point worth considering. Take away the fraud, rewind to the actual evidence, and what remains?
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Replying to @GidMK
In terms of trials that are well-designed, non-fraudulent, powered enough to show important outcomes, peer reviewed and published? Vallejos and Mahmud.
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Replying to @EdoajoEric @GidMK
Vallejos N= around 250 per arm if I remember correctly, showed a 34% reduction in hospitalization that didnt reach statistical significance with 0.2mg/kg-ish x 2 doses. Mahmud N=250 per arm fixed 12mg ivm dose+doxy showed 50% less deterioration which was statistically significant
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Also Mohan, showing no stat sig, but benefits for placebo at day 3/10 and benefit for ivm at day 5. In Vallejos, there was a 34% reduction in hospitalization but a 33% increase in mechanical ventilation in the ivm group (both non-sig)
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Replying to @GidMK @EdoajoEric
Even Mahmud had some variables where placebo did better than ivm! Not a slam dunk, sure, but once you get rid of the fraud it's really inconclusive imo
2 replies 0 retweets 3 likesThanks. Twitter will use this to make your timeline better. UndoUndo
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