7/n But this isn't scientific. They haven't rerun the actual study, they've just run one model excluding Elgazzar I noted this issue in a thread AGES agohttps://twitter.com/GidMK/status/1416290862724644867?s=20 …
Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him
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Health Nerd Retweeted Health Nerd
7/n But this isn't scientific. They haven't rerun the actual study, they've just run one model excluding Elgazzar I noted this issue in a thread AGES agohttps://twitter.com/GidMK/status/1416290862724644867?s=20 …
Health Nerd added,
8/n It's a HUGE issue for a very simple reason - once you've gotten rid of the likely fraudulent Elgazzar trial, the ENTIRE MORTALITY BENEFIT comes from one very bad trial This means that even the most basic sensitivity analysis removes the effect entirely
9/n So when the authors say that the "leading outcome conclusions" remain unchanged, they are factually mistaken. Indeed, it appears that their entire result now relies on a single study with very substantial issues
10/n Whether or not this means that you can still get a marginally statistically significant result in your model, it means that the certainty of that result is ENORMOUSLY downgraded, and thus the conclusions (below) are clearly reversedpic.twitter.com/4jptUFo9hw
11/n The Niaee trial is worrisome in particular because, despite numerous efforts, the authors have refused to share any data with either myself or
@K_Sheldrick
At this point, that's a huge red flag
12/n Finally, I will note that the letter is also rather poorly timed, as just this morning we confirmed that another study the authors have included in their analysis is almost certainly fake 
13/n I think the most rigorous scientific step, at this point, is for the authors to revise their actual study I can't imagine leaving a meta-analysis containing likely fraudulent research up as-is myself, but perhaps that's just me
14/n A minor addition - another letter published alongside this makes a similar argument, but in a moment of what I can only call scientific absurdity includes another trial with serious concerns in the REVISED analysispic.twitter.com/av013wkhR2
15/n It's rather, uh, strange to see people arguing that potential fraud has not impacted their results while still including potential fraud You can read about this study here:https://www.buzzfeednews.com/article/stephaniemlee/ivermectin-covid-study-suspect-data …
I’ll be curious what happens to the meta analysis if Together Trial results get incorporated post publication.
Completely reverses the findings, with a fairly strong null result for ivermectin
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