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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Sep 6

      This study is a common citation of ivermectin believers, has been reported widely, and I think is a great teaching tool in how little effort it takes to be critical about research findings 1/npic.twitter.com/YDZNB1JP5R

      19 replies 279 retweets 881 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Sep 6

      2/n The study is here, and has an objectively large impact with nearly a dozen news stories and an Altmetric of 2750https://www.medrxiv.org/content/10.1101/2021.05.31.21258081v1 …

      1 reply 7 retweets 76 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Sep 6

      3/n The study is pretty simple - 116 people with Covid-19, randomized to either receive ivermectin or a placebo Reported results were viral load, and more specifically proportion of people with Ct>30 at various time points on PCRpic.twitter.com/ozXyxZwAOj

      2 replies 6 retweets 75 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK Sep 6

      4/n The authors report a marginally significant benefit at various days using an uncorrected logistic regression, and from this the massive attention sprangpic.twitter.com/5xk5vLDkrH

      2 replies 7 retweets 78 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK Sep 6

      5/n One of the first things I do when I read randomized trials like this is look at their pre-registration. This is basically what the authors SAID they would do registered BEFORE they did it Here's the pre-reg for this trial:https://clinicaltrials.gov/ct2/show/NCT04429711?term=NCT04429711&draw=2&rank=1 …

      2 replies 10 retweets 105 likes
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    6. Health Nerd‏Verified account @GidMK Sep 6

      6/n Immediately on looking at the pre-registration, there is a HUGE discrepancy with the published results Here's what the authors pre-registered as their exclusion and the flow chart from the study. Notice the difference?pic.twitter.com/eMFPtwG9Y6

      4 replies 10 retweets 93 likes
      Show this thread
    7. Health Nerd‏Verified account @GidMK Sep 6

      7/n It appears that the authors have added an extra exclusion criteria that is applied AFTER randomization and treatment. This is "tested Ct>35" in the first two testspic.twitter.com/V5ZfCZWhv7

      5 replies 10 retweets 109 likes
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    8. Aline Magalhaes, MD‏ @alinefortuna2 Sep 7
      Replying to @GidMK

      What would you say if the PI replace de study drug (yes, you heard it right) and still move forward with the trial?”

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK Sep 7
      Replying to @alinefortuna2

      I've done this in a trial (the legislation changed and we had to update the medication) as long as you're open about the change and the reasons for it there should be no issue

      1:48 PM - 7 Sep 2021
      • 1 Like
      • Aline Magalhaes, MD
      1 reply 0 retweets 1 like
        1. New conversation
        2. Aline Magalhaes, MD‏ @alinefortuna2 Sep 7
          Replying to @GidMK

          In that case, since the drug changed (and is the one being investigated) wouldn’t you expect that sample size, safety endpoints etc would be obsolete?

          1 reply 0 retweets 0 likes
        3. Health Nerd‏Verified account @GidMK Sep 7
          Replying to @alinefortuna2

          Not necessarily. Depends on the situation, the drug etc. This is why openness is more important than anything for clinical trials

          0 replies 0 retweets 1 like
        4. End of conversation

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