11/n If you add these people back in, the results of the study entirely lose their significance At day 10, this would be 87% of the ivm and 77% of the control reaching the primary endpoint, p=0.16pic.twitter.com/UjgaGpjYFw
Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him
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11/n If you add these people back in, the results of the study entirely lose their significance At day 10, this would be 87% of the ivm and 77% of the control reaching the primary endpoint, p=0.16pic.twitter.com/UjgaGpjYFw
12/n In addition, the authors pre-registered 3 primary outcomes. I can only see one (viral clearance) properly assessed in the paper (shedding is somewhat assessed, but it looks like they didn't get enough samples to statistically analyse this)pic.twitter.com/wv4hnBhNNE
13/n Anyway, the main issue is that, if you use the pre-registered protocol, the study appears to have null results
And yet, reported as positive to massive worldwide acclaim 
14/n This has nothing to do with fraud, takes literally minutes to check, and I encourage everyone to do so. Please let me know if I've made an error somewhere
15/n Also, to be clear - I'm not accusing the authors of any research misconduct, this is just very basic due diligence that everyone should do for any trial that they read
You are overlooking the fact that the CT was changed after he cultured the virus and determined that no live virus could be find over 30 cycles. Your point doesn't invalidate the result at all. Significant differences could also be found by comparing daily viral loads as well.
That is immaterial to the issue at hand, which is to do with post-hoc alterations to study protocols. The proper analysis would be including all patients randomised and treated, this is known as the "intention to treat" method of analysis
Don't you think there is a more important point to discuss, ie the results of this study for example?
If you run the pre registered analysis the results appear to be null, which means that this question is fundamental to whether this study shows a benefit or no benefit for ivm
Not true. There is also a statistically different at day 6 and 8.pic.twitter.com/lAb0fxfg0f
You've missed the point of my thread
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