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Not to mention we can start a trial today and still need to make a decision about what to do tomorrow. EBM is more than just the best evidence, it includes patient values and expertise (good old venn diagram)
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Oh and said expertise should ideally come from ID and Developmental Pediatricians.
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I think you do the best you can. Problem now is data for mask use in schools is scant, and an RCT could help tremendously, and see if you could measure any short-term harms in the process.
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And this could set up the appropriate longitudinal studies to study long-term effects, so at least we may have more answers for the next pandemic. We’ll just have to deal with the uncertainties for this one.
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