To put it another way - there's no reasonable argument that in one study a similar regimen resulted in 80% improvement in mortality but in another it's a "flaw" when it resulted in no improvement in mortality. Either it is or isn't an issue
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Replying to @GidMK
I will remind you that I have said nothing about any other study. I've only written about the TOGETHER study. Everything else you ascribe to me is... strange?
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Replying to @alexandrosM
Precisely my point. This is the same regimen that other studies that found a benefit used. So why are you only critiquing the Together trial for this reason? If we were to discard evidence that used this regimen, there's no RCTs that indicate a benefit for ivermectin
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Replying to @GidMK
Ok, so looking at the Niaee trial now. Can you confirm if I have these facts right? - Ivermectin is combined with HCQ, Heparin, Oxygen - It's a trial that happened in June/July 2020pic.twitter.com/0JoyBCBKUh
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Replying to @alexandrosM
Yep! And found a mortality reduction of ~70% in favour of ivermectin. Indeed, the ~only~ RCT to have found such a statistically significant benefit
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Replying to @GidMK
But why do you say that the protocols were "the same" or "similar", since several other interventions were involved?
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Replying to @alexandrosM
Because the things that you are saying are an issue for Together were the same - ivermectin dosage, timing etc, although to be fair Together gave a higher dose to most participants
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Replying to @GidMK
How does what I say affect what you consider to be the same?
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Replying to @GidMK
You said these trials used "the same regimen". When I ask why you say these regimens are the same, given that they're significantly different, you refer to what I wrote. Which shouldn't really affect how you compare. Did they use "the same regimen" or not?
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They used the same ivermectin regimen, and other regimen changes were similar between groups. Like I said, if your critique made any sense, it would apply equally to these other RCTs
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