Niaee gave between 1-3 doses, didn't specify empty/full, and gave to more advanced disease than Together. It's just this litany of non-issues that no one even tries to pick out for positive trials
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Replying to @GidMK @alexandrosM
Actually, having had a quick look through the trial protocols, I can't find a single study that found benefits that adhered to all those points you've raised. Does that mean that you believe that there's no evidence for ivermectin working, or are they only issues in Together?
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Replying to @GidMK
Are you saying that if no study followed all the best practice elements that IVM proponents recommend, then a study that followed none of them is just as valid as one that followed half of them, or one that followed 90% of them?
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Replying to @alexandrosM
No. I'm saying that there are numerous studies with positive results that you have not criticized for these exact same "flaws"
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Replying to @alexandrosM
Then the Niaee study has the same conjunction. In addition, they gave lower doses of ivermectin. And it is the only RCT to show any statistically significant improvement in mortality for ivermectin
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Replying to @GidMK @alexandrosM
To put it another way - there's no reasonable argument that in one study a similar regimen resulted in 80% improvement in mortality but in another it's a "flaw" when it resulted in no improvement in mortality. Either it is or isn't an issue
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Replying to @GidMK
I will remind you that I have said nothing about any other study. I've only written about the TOGETHER study. Everything else you ascribe to me is... strange?
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Replying to @alexandrosM
Precisely my point. This is the same regimen that other studies that found a benefit used. So why are you only critiquing the Together trial for this reason? If we were to discard evidence that used this regimen, there's no RCTs that indicate a benefit for ivermectin
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Replying to @GidMK
Ok, so looking at the Niaee trial now. Can you confirm if I have these facts right? - Ivermectin is combined with HCQ, Heparin, Oxygen - It's a trial that happened in June/July 2020pic.twitter.com/0JoyBCBKUh
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Yep! And found a mortality reduction of ~70% in favour of ivermectin. Indeed, the ~only~ RCT to have found such a statistically significant benefit
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