Sure. Many of the positive trials, such as Niaee, have similar dosing schedules as Together. Some of them gave lower doses. But the only trial you have raised this objection to is the one with null results
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Replying to @GidMK @alexandrosM
Any response here? Why is this dosing regimen an issue for Together but not studies that show positive results?
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Replying to @GidMK
I will look into that trial and let you know. (just woke up btw)
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Replying to @alexandrosM
Cool, me too. So, why is Niaee and/or the other positive studies where they gave lower or similar doses of ivermectin fine but Together is bad? Is it simply because of the null result?
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Replying to @GidMK
Is it simply the dose you're comparing? Not stage of disease, repetition, empty/full stomach, etc?
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Replying to @alexandrosM
Niaee gave between 1-3 doses, didn't specify empty/full, and gave to more advanced disease than Together. It's just this litany of non-issues that no one even tries to pick out for positive trials
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Replying to @GidMK @alexandrosM
Actually, having had a quick look through the trial protocols, I can't find a single study that found benefits that adhered to all those points you've raised. Does that mean that you believe that there's no evidence for ivermectin working, or are they only issues in Together?
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Replying to @GidMK
Are you saying that if no study followed all the best practice elements that IVM proponents recommend, then a study that followed none of them is just as valid as one that followed half of them, or one that followed 90% of them?
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Replying to @alexandrosM
No. I'm saying that there are numerous studies with positive results that you have not criticized for these exact same "flaws"
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Then the Niaee study has the same conjunction. In addition, they gave lower doses of ivermectin. And it is the only RCT to show any statistically significant improvement in mortality for ivermectin
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Replying to @GidMK @alexandrosM
To put it another way - there's no reasonable argument that in one study a similar regimen resulted in 80% improvement in mortality but in another it's a "flaw" when it resulted in no improvement in mortality. Either it is or isn't an issue
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