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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Aug 28
      Replying to @alexandrosM

      Sure. Many of the positive trials, such as Niaee, have similar dosing schedules as Together. Some of them gave lower doses. But the only trial you have raised this objection to is the one with null results

      2 replies 0 retweets 46 likes
    2. Health Nerd‏Verified account @GidMK Aug 29
      Replying to @GidMK @alexandrosM

      Any response here? Why is this dosing regimen an issue for Together but not studies that show positive results?

      2 replies 0 retweets 43 likes
    3. Alexandros Marinos‏ @alexandrosM Aug 29
      Replying to @GidMK

      I will look into that trial and let you know. (just woke up btw)

      4 replies 0 retweets 10 likes
    4. Health Nerd‏Verified account @GidMK Aug 29
      Replying to @alexandrosM

      Cool, me too. So, why is Niaee and/or the other positive studies where they gave lower or similar doses of ivermectin fine but Together is bad? Is it simply because of the null result?

      1 reply 0 retweets 29 likes
    5. Alexandros Marinos‏ @alexandrosM Aug 29
      Replying to @GidMK

      Is it simply the dose you're comparing? Not stage of disease, repetition, empty/full stomach, etc?

      1 reply 0 retweets 12 likes
    6. Health Nerd‏Verified account @GidMK Aug 29
      Replying to @alexandrosM

      Niaee gave between 1-3 doses, didn't specify empty/full, and gave to more advanced disease than Together. It's just this litany of non-issues that no one even tries to pick out for positive trials

      1 reply 0 retweets 29 likes
    7. Health Nerd‏Verified account @GidMK Aug 29
      Replying to @GidMK @alexandrosM

      Actually, having had a quick look through the trial protocols, I can't find a single study that found benefits that adhered to all those points you've raised. Does that mean that you believe that there's no evidence for ivermectin working, or are they only issues in Together?

      1 reply 0 retweets 39 likes
    8. Alexandros Marinos‏ @alexandrosM Aug 29
      Replying to @GidMK

      Are you saying that if no study followed all the best practice elements that IVM proponents recommend, then a study that followed none of them is just as valid as one that followed half of them, or one that followed 90% of them?

      1 reply 0 retweets 14 likes
    9. Health Nerd‏Verified account @GidMK Aug 29
      Replying to @alexandrosM

      No. I'm saying that there are numerous studies with positive results that you have not criticized for these exact same "flaws"

      1 reply 0 retweets 33 likes
    10. Alexandros Marinos‏ @alexandrosM Aug 29
      Replying to @GidMK

      What if I'm criticizing the conjunction of flaws?

      1 reply 0 retweets 12 likes
      Health Nerd‏Verified account @GidMK Aug 29
      Replying to @alexandrosM

      Then the Niaee study has the same conjunction. In addition, they gave lower doses of ivermectin. And it is the only RCT to show any statistically significant improvement in mortality for ivermectin

      5:05 PM - 29 Aug 2021
      • 32 Likes
      • Bga Mads Steven B Morten Elsøe No Federalist Society 5th Column Thank You Ryan Armstrong James Pitt Javier R Paiva
      1 reply 0 retweets 32 likes
        1. Health Nerd‏Verified account @GidMK Aug 29
          Replying to @GidMK @alexandrosM

          To put it another way - there's no reasonable argument that in one study a similar regimen resulted in 80% improvement in mortality but in another it's a "flaw" when it resulted in no improvement in mortality. Either it is or isn't an issue

          2 replies 0 retweets 41 likes
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