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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Dr. Eric Osgood MD‏ @EdoajoEric Aug 24
      Replying to @GidMK @K_Sheldrick @VaxScan

      The best evidence available should guide practice.

      3 replies 0 retweets 6 likes
    2. Health Nerd‏Verified account @GidMK Aug 24
      Replying to @EdoajoEric @K_Sheldrick @VaxScan

      And if the best evidence available cannot exclude serious harm from the treatment?

      1 reply 0 retweets 6 likes
    3. Kyle Sheldrick‏ @K_Sheldrick Aug 24
      Replying to @GidMK @EdoajoEric @VaxScan

      Then it comes down to a risk of serious harm vs a risk of serious benefit. E.g. many treatment options for some cancers are known to definitely cause harm, but the groups are small enough we can't be certain of benefit.

      2 replies 0 retweets 4 likes
    4. Health Nerd‏Verified account @GidMK Aug 24
      Replying to @K_Sheldrick @EdoajoEric @VaxScan

      But surely in that context a treatment should only be used within a pretty structured modality, with explicit consent etc? As a patient I'd be really worried if I was at potential harm and it wasn't clearly outlined

      1 reply 0 retweets 4 likes
    5. Kyle Sheldrick‏ @K_Sheldrick Aug 24
      Replying to @GidMK @EdoajoEric @VaxScan

      Oh yeah I completely agree with that, can't pretend to be more certain than you are, can't hide potential harm, can't override autonomy. That being said... 1/

      1 reply 0 retweets 3 likes
    6. Kyle Sheldrick‏ @K_Sheldrick Aug 24
      Replying to @K_Sheldrick @GidMK and

      If point estimate for drug x for covid is 20% relative reduction in mortality, but 95% CI crosses 1, and we decline to prescribed. Then with more studies the CI tightens and point estimate doesn't change. Now clear it works 100 million patients not treated. 2/

      1 reply 0 retweets 9 likes
    7. Kyle Sheldrick‏ @K_Sheldrick Aug 24
      Replying to @K_Sheldrick @GidMK and

      Do we have moral culpability for those that died that would have survived? I'm not sure there is such a huge difference between harm caused and harm not prevented. Waiting for more info is still an active decision not to treat. 3/3

      2 replies 0 retweets 9 likes
    8. Health Nerd‏Verified account @GidMK Aug 24
      Replying to @K_Sheldrick @EdoajoEric @VaxScan

      But the converse is also extremely problematic - HCQ we justified based on similar arguments and it appears to cause modest increases in death rates from covid. If the end result is a treatment that does cause harm, what is the moral culpability?

      5 replies 0 retweets 3 likes
    9. Dr. Eric Osgood MD‏ @EdoajoEric Aug 24
      Replying to @GidMK @K_Sheldrick @VaxScan

      We cant allow "but HCQ..." to be the harbinger of therapeutic nihilism.

      3 replies 0 retweets 4 likes
    10. Dr. Eric Osgood MD‏ @EdoajoEric Aug 24
      Replying to @EdoajoEric @GidMK and

      On the other hand there's "but methylprednisolone/dexamethasone." Based on the numbers needed to treat re: in hospital mortality, how many died awaiting physicians to accumulate a gigantic trial to spoonfeed them a conclusion their pathophys/pharm reasoning should have told them.

      1 reply 0 retweets 6 likes
      Health Nerd‏Verified account @GidMK Aug 24
      Replying to @EdoajoEric @K_Sheldrick @VaxScan

      You could say that this is just an argument for better/quicker trials tho - we could've had trial results from large research projects months earlier during covid if we'd had our shit together. How many lives would it have saved if we'd gotten the fluvox results in May 2020?

      10:54 PM - 24 Aug 2021
      • 4 Likes
      • df Tweetsing Chris Street, 🇬🇧 MBA, MSc (Medicinal Chemistry) Kyle Sheldrick
      2 replies 0 retweets 4 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK Aug 24
          Replying to @GidMK @EdoajoEric and

          Like, obviously in absence of all evidence it's reasonable to try whatever you think is best, but the absence of evidence at a certain point is an active choice because often people would rather use treatments than trial them (Gilead/remdesivir is a good example)

          2 replies 0 retweets 1 like
        3. Kyle Sheldrick‏ @K_Sheldrick Aug 24
          Replying to @GidMK @EdoajoEric @VaxScan

          I agree reasonably strongly for drugs early in patent, but for repurposed drugs harder to apply.

          0 replies 0 retweets 2 likes
        4. End of conversation
        1. New conversation
        2. Angela Reiersen, MD, MPE‏ @AngelaReiersen Aug 25
          Replying to @GidMK @EdoajoEric and

          And how do you think we could have got our first small trial done that fast, let alone a larger one? Easier said than done. You might think with so many people sick at once, it would be easy to run a trial during a pandemic, but it’s not: Lots of barriers.

          1 reply 0 retweets 2 likes
        3. Michael Edwards.‏ @MichaelPaulEdw1 Aug 25
          Replying to @AngelaReiersen @GidMK and

          I think the "shit together" is the clause of barriers he was referring to.

          0 replies 0 retweets 1 like
        4. End of conversation

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