The difficulty with this approach is you end up destroying the literature. There's always some new standard that /could/ have been applied once the trial gives a result you don't like. BIRD/FLCCC et al never reject "positive" trials with similar designs.https://twitter.com/BIRDGroupUK/status/1425880281618190337 …
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I complained when they were only going to use a single dose. I thought they had increased it to 5 days of dosing.
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