Summary results for ivermectin for COVID-19 from the large TOGETHER trial were just released No benefit whatsoever for ivermectin on risk of hospitalization or mortality in a mild outpatient grouppic.twitter.com/5eZj0pc5V6
Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him
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Summary results for ivermectin for COVID-19 from the large TOGETHER trial were just released No benefit whatsoever for ivermectin on risk of hospitalization or mortality in a mild outpatient grouppic.twitter.com/5eZj0pc5V6
The slides are here: https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/GR-Slides-08-06-21.pdf … The preprint should be coming out soon, but as of yet can only assess the trial based on the protocol from other results published from this trial (it's pretty solid)
Adding these results into the meta-analytic model excluding Elgazzar and Niaee gives you an idea of the plausible benefit of ivermectin at this point (not great)pic.twitter.com/0l4NiVur6i
Worth waiting for the study to be published for any certainty, but at this point I'd say there's still a plausible minor benefit for ivermectin (on the order of 10% benefit) but any enormous benefits have been largely excluded by the data to date
In other words, it's still possible ivermectin helps a bit, but it is very unlikely that it is a "miracle drug" that everyone should be taking at this point
TOGETHER is the largest, most well-conducted ivermectin study to date, and it was in low-risk outpatients Which means the two main arguments from the ivermectin proponents simply no longer make any sense at all
Also, people are talking about minor dosing differences (0.4mcg/kg vs 0.6mcg/kg) as if that's meaningful which is HILARIOUS because the dosage used in TOGETHER is higher than most of the studies showing massive mortality benefits
One more point - there DOES appear to be a benefit in these slides from fluvoxamine for hospitalization/ED. I don't know enough about the literature on fluvoxamine to comment, but this looks very encouraging in isolationpic.twitter.com/X7Z1RjEZhL
I wrote about this all in a new piecehttps://link.medium.com/hEDDYqEyEib
That’s disappointing. I had high hopes. It goes to show emotion goes a long way for selling something, but can never replace cold hard facts.
Yes I feel that very much
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