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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Aug 11

      Summary results for ivermectin for COVID-19 from the large TOGETHER trial were just released No benefit whatsoever for ivermectin on risk of hospitalization or mortality in a mild outpatient grouppic.twitter.com/5eZj0pc5V6

      166 replies 1,001 retweets 2,081 likes
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    2. Health Nerd‏Verified account @GidMK Aug 11

      The slides are here: https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/GR-Slides-08-06-21.pdf … The preprint should be coming out soon, but as of yet can only assess the trial based on the protocol from other results published from this trial (it's pretty solid)

      14 replies 43 retweets 161 likes
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    3. Health Nerd‏Verified account @GidMK Aug 11

      Adding these results into the meta-analytic model excluding Elgazzar and Niaee gives you an idea of the plausible benefit of ivermectin at this point (not great)pic.twitter.com/0l4NiVur6i

      13 replies 40 retweets 191 likes
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    4. Health Nerd‏Verified account @GidMK Aug 11

      Worth waiting for the study to be published for any certainty, but at this point I'd say there's still a plausible minor benefit for ivermectin (on the order of 10% benefit) but any enormous benefits have been largely excluded by the data to date

      10 replies 27 retweets 176 likes
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    5. Health Nerd‏Verified account @GidMK Aug 11

      In other words, it's still possible ivermectin helps a bit, but it is very unlikely that it is a "miracle drug" that everyone should be taking at this point

      11 replies 45 retweets 215 likes
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    6. Health Nerd‏Verified account @GidMK Aug 11

      TOGETHER is the largest, most well-conducted ivermectin study to date, and it was in low-risk outpatients Which means the two main arguments from the ivermectin proponents simply no longer make any sense at all

      21 replies 53 retweets 231 likes
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    7. Health Nerd‏Verified account @GidMK Aug 11

      Also, people are talking about minor dosing differences (0.4mcg/kg vs 0.6mcg/kg) as if that's meaningful which is HILARIOUS because the dosage used in TOGETHER is higher than most of the studies showing massive mortality benefits

      16 replies 20 retweets 160 likes
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      Health Nerd‏Verified account @GidMK Aug 11

      One more point - there DOES appear to be a benefit in these slides from fluvoxamine for hospitalization/ED. I don't know enough about the literature on fluvoxamine to comment, but this looks very encouraging in isolationpic.twitter.com/X7Z1RjEZhL

      6:19 PM - 11 Aug 2021
      • 22 Retweets
      • 143 Likes
      • Woody Nist Josh 🐔 kfunk937 Longan@🇯🇵日本⇔🇹🇭バンコク 白鷺烏 Mathematiker plädiert für Ruhe und Rationalität tanja stark Jon Atkins Syed Shahrul Naz
      12 replies 22 retweets 143 likes
        1. Health Nerd‏Verified account @GidMK Aug 11

          I wrote about this all in a new piecehttps://link.medium.com/hEDDYqEyEib 

          9 replies 25 retweets 111 likes
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        1. Grand Beggar‏ @GrandBeggar Aug 11
          Replying to @GidMK

          Did all of this conjecture about ivermectin stem from one computer model that indicated ivermectin bonds to covid proteins? How did this happen? Who is benefiting from this?

          0 replies 0 retweets 1 like
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        1. Nathan  🛶 🚴‍♂️ 🏕️‏ @NaFun Aug 11
          Replying to @GidMK

          Reduces cytokineshttps://www.covid19treatmentguidelines.nih.gov/therapies/immunomodulators/fluvoxamine/ …

          0 replies 0 retweets 0 likes
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        2. Roby Bhattacharyya‏ @roby_bhatt Aug 11
          Replying to @GidMK

          3rd promising result for fluvoxamine - I agree, encouraging as outpt Rx; eager to see more data. Prior small RCT (0/80 worsened, vs 6/72 placebo): https://jamanetwork.com/journals/jama/fullarticle/2773108 … & prospective cohort (opt-in to Rx after exposure; 0/65 hosp, vs 6/48 placebo):https://academic.oup.com/ofid/article/8/2/ofab050/6124100 …

          1 reply 1 retweet 5 likes
        3. Edward Nirenberg‏ @ENirenberg Aug 11
          Replying to @roby_bhatt @GidMK

          It's very intriguing but honestly I don't feel great about it given the tiny sample sizes. The relative silver lining of this current wave with the delta variant though is that we might actually get large numbers to know which medications are and aren't efficacious

          1 reply 0 retweets 3 likes
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        2. Dr. Joe‏ @NoLogoJoe Aug 11
          Replying to @GidMK

          Pardon? Fluvoxamine, as in Luvox, as in SSRI anti-depressant? Bizarre, yet interesting news, must be in relation to its anti-inflam effects, am guessing. Its generic now in Canada, so not too expensive of an option, wondering what price per pill in US is, though.

          1 reply 0 retweets 1 like
        3. Andrew Jacklin‏ @EM_Dr_Jacklin Aug 12
          Replying to @NoLogoJoe @GidMK

          Yes, how on earth did anyone decide to study that one out of all the drugs out there? Well, whoever it was, if it pans out good on them but I'd love to know the logic behind it.

          1 reply 0 retweets 1 like
        4. Show replies
        1. Mr. B‏ @yeahnaa333 Aug 12
          Replying to @GidMK

          fluvoxamine the anti-depressant?

          0 replies 0 retweets 0 likes
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        1. Dave Liss‏ @dave_liss Aug 12
          Replying to @GidMK

          Where did the fluvoxamine data come from?

          0 replies 0 retweets 0 likes
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