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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Aug 11

      Summary results for ivermectin for COVID-19 from the large TOGETHER trial were just released No benefit whatsoever for ivermectin on risk of hospitalization or mortality in a mild outpatient grouppic.twitter.com/5eZj0pc5V6

      166 replies 1,001 retweets 2,081 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Aug 11

      The slides are here: https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/GR-Slides-08-06-21.pdf … The preprint should be coming out soon, but as of yet can only assess the trial based on the protocol from other results published from this trial (it's pretty solid)

      14 replies 43 retweets 161 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Aug 11

      Adding these results into the meta-analytic model excluding Elgazzar and Niaee gives you an idea of the plausible benefit of ivermectin at this point (not great)pic.twitter.com/0l4NiVur6i

      13 replies 40 retweets 191 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK Aug 11

      Worth waiting for the study to be published for any certainty, but at this point I'd say there's still a plausible minor benefit for ivermectin (on the order of 10% benefit) but any enormous benefits have been largely excluded by the data to date

      10 replies 27 retweets 176 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK Aug 11

      In other words, it's still possible ivermectin helps a bit, but it is very unlikely that it is a "miracle drug" that everyone should be taking at this point

      11 replies 45 retweets 215 likes
      Show this thread
      Health Nerd‏Verified account @GidMK Aug 11

      TOGETHER is the largest, most well-conducted ivermectin study to date, and it was in low-risk outpatients Which means the two main arguments from the ivermectin proponents simply no longer make any sense at all

      5:17 PM - 11 Aug 2021
      • 53 Retweets
      • 231 Likes
      • Frank Rodriguez Josh 🐔 Mathematiker plädiert für Ruhe und Rationalität Marielle Jon Atkins Mark Lacomber aishoni 嵐 🇲🇾💛💍👶💃🏻✨ Robert Clark Syed Shahrul Naz
      21 replies 53 retweets 231 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK Aug 11

          Also, people are talking about minor dosing differences (0.4mcg/kg vs 0.6mcg/kg) as if that's meaningful which is HILARIOUS because the dosage used in TOGETHER is higher than most of the studies showing massive mortality benefits

          16 replies 20 retweets 160 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK Aug 11

          One more point - there DOES appear to be a benefit in these slides from fluvoxamine for hospitalization/ED. I don't know enough about the literature on fluvoxamine to comment, but this looks very encouraging in isolationpic.twitter.com/X7Z1RjEZhL

          12 replies 22 retweets 143 likes
          Show this thread
        4. Health Nerd‏Verified account @GidMK Aug 11

          I wrote about this all in a new piecehttps://link.medium.com/hEDDYqEyEib 

          9 replies 25 retweets 111 likes
          Show this thread
        5. End of conversation
        1. New conversation
        2. bad_stats‏ @thebadstats Aug 11
          Replying to @GidMK

          That just means it's time to move on to Fluvoxamine! Except fluvoxamine might actually work?pic.twitter.com/uRRdjAfLT2

          1 reply 0 retweets 7 likes
        3. Health Nerd‏Verified account @GidMK Aug 11
          Replying to @thebadstats

          Don't know enough about the data to comment on fluvoxamine. It does look good from these slides!

          1 reply 0 retweets 4 likes
        4. Show replies
        1. New conversation
        2. Go Browns‏ @IsHueFiredYet Aug 11
          Replying to @GidMK

          Why ppl cling to Ivermectin as a miracle drug is beyond me people can shift their focus to a therapeutic that has shown great efficacy in early hospitalized patients by inhibiting GM-CSF and preventing ventilation/death - #Lenzilumab. 520 Pt P3 trial -> https://www.medrxiv.org/content/10.1101/2021.05.01.21256470v1.full.pdf …

          2 replies 0 retweets 7 likes
        3. Show replies
        1. Fyodor‏ @Fyodor32768 Aug 11
          Replying to @GidMK

          I would be interested in hearing your thoughts on the Fluvoxomine results

          0 replies 0 retweets 1 like
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        1. New conversation
        2. David Boulware, MD MPH‏Verified account @boulware_dr Aug 11
          Replying to @GidMK

          @GidMK population enrolled was age >50yo or with a co-morbidity, so a moderate risk population -- but indeed with early mild disease (at trial entry)

          1 reply 0 retweets 5 likes
        3. Health Nerd‏Verified account @GidMK Aug 11
          Replying to @boulware_dr

          Good point! I think in this context I would classify as mild, because the other trials have been on hospitalized/ICU admitted which have been classified as moderate/severe respectively

          2 replies 0 retweets 4 likes
        4. Show replies

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