Summary results for ivermectin for COVID-19 from the large TOGETHER trial were just released No benefit whatsoever for ivermectin on risk of hospitalization or mortality in a mild outpatient grouppic.twitter.com/5eZj0pc5V6
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Adding these results into the meta-analytic model excluding Elgazzar and Niaee gives you an idea of the plausible benefit of ivermectin at this point (not great)pic.twitter.com/0l4NiVur6i
Worth waiting for the study to be published for any certainty, but at this point I'd say there's still a plausible minor benefit for ivermectin (on the order of 10% benefit) but any enormous benefits have been largely excluded by the data to date
In other words, it's still possible ivermectin helps a bit, but it is very unlikely that it is a "miracle drug" that everyone should be taking at this point
TOGETHER is the largest, most well-conducted ivermectin study to date, and it was in low-risk outpatients Which means the two main arguments from the ivermectin proponents simply no longer make any sense at all
Also, people are talking about minor dosing differences (0.4mcg/kg vs 0.6mcg/kg) as if that's meaningful which is HILARIOUS because the dosage used in TOGETHER is higher than most of the studies showing massive mortality benefits
One more point - there DOES appear to be a benefit in these slides from fluvoxamine for hospitalization/ED. I don't know enough about the literature on fluvoxamine to comment, but this looks very encouraging in isolationpic.twitter.com/X7Z1RjEZhL
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