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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Jul 6

      Another day, another systematic review and meta-analysis of the same ivermectin research published This one is positive. I don't think it should be 1/npic.twitter.com/f9k8hfvidy

      21 replies 103 retweets 300 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Jul 6

      2/n Study is here, and generally it looks fine - search strategy was decent, they followed most guidelines (I.e. PRISMA), and overall the methodology was pretty reasonable for the stated purposehttps://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab358/6316214#.YORtErIpyh8.twitter …

      1 reply 4 retweets 41 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Jul 6

      Health Nerd Retweeted Health Nerd

      3/n In fact, it is amazingly similar to the other systematic review that I looked at recently, down to THE SAME DETAILS THAT ARE WEIRD This whole thing feels like some bizarre deja-vuhttps://twitter.com/GidMK/status/1407140602009985025?s=20 …

      Health Nerd added,

      Health NerdVerified account @GidMK
      This new systematic review/meta-analysis of ivermectin for COVID-19 has come out, and everyone's asking me to review it My take - decent study, but the devil's in the details 1/n pic.twitter.com/RB0dfYe5vr
      Show this thread
      1 reply 5 retweets 51 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK Jul 6

      4/n Skipping over the other methodological stuff (which was VERY similar), there is still a worry about publication bias in this newer review. Potentially an issue, hard to exclude as a problempic.twitter.com/Sa3NBfx5em

      1 reply 5 retweets 44 likes
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    5. Health Nerd‏Verified account @GidMK Jul 6

      5/n The authors did attempt to test for this (good!) and found no strong evidence for publication bias So some improvement there

      1 reply 3 retweets 41 likes
      Show this thread
    6. Health Nerd‏Verified account @GidMK Jul 6

      6/n But, as before, the devil really is in the details This review included those same two studies that I mentioned before - Elgazzar and Niaee This time, however, they were rated as at LOW risk of bias (i.e. high quality)pic.twitter.com/5cFzdHiGde

      2 replies 7 retweets 51 likes
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    7. Health Nerd‏Verified account @GidMK Jul 6

      7/n Now, it's perhaps debatable whether these have some concerns or are at very high risk of bias. I think the latter. But I genuinely cannot see how anyone who read the studies could think that they were at low risk of bias

      1 reply 3 retweets 47 likes
      Show this thread
    8. Health Nerd‏Verified account @GidMK Jul 6

      8/n Let's compare to another paper - Mahmud (2020) is a study that everyone would agree is at low risk of bias. It is just incredibly well done Also, it found a benefit for ivermectinhttps://journals.sagepub.com/doi/10.1177/03000605211013550?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed …

      3 replies 7 retweets 50 likes
      Show this thread
    9. Dr. Eric Osgood MD‏ @EdoajoEric Aug 6
      Replying to @GidMK

      If mahmud's study was well done + showed benefit, and only 16% of professional medical societal treatment guidelines in infectious diseases are based on even one single RCT (https://pubmed.ncbi.nlm.nih.gov/20946067/ ) then why, in a pandemic, are we applying an unpredented data hurdle to a safe rx?

      2 replies 0 retweets 6 likes
      Health Nerd‏Verified account @GidMK Aug 6
      Replying to @EdoajoEric

      There are two better trials that show no benefit at all. If you pick and choose your evidence, you can come to whatever conclusion you want

      2:36 PM - 6 Aug 2021
      • 1 Like
      • Chris Donnelly
      0 replies 0 retweets 1 like

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