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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Jul 28

      Meta-analysis really is just a simple statistical aggregation of results. Indeed, the most basic way to meta-analyze studies is just to use a mean or median of their point-estimates

      2 replies 5 retweets 59 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Jul 28

      But simple means/medians can be misleading - we don't really want a study of 10,000 to have the same weighting as a study of 10, but that's what a simple average provides

      2 replies 1 retweet 49 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Jul 28

      When we run a meta-analytic model, what we are actually doing is generating a WEIGHTED mean/median, and confidence interval. Essentially, we take all of the means and SEs, and based on that our model weights them with bigger studies generally contributing more to the modelpic.twitter.com/8WrRkjVflu

      1 reply 1 retweet 35 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK Jul 28

      You'll notice I've said nothing about the underlying quality of the evidence That's because META-ANALYSIS HAS NOTHING TO DO WITH QUALITY OF EVIDENCE

      4 replies 6 retweets 74 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK Jul 28

      You can throw anything into a meta-analysis model. Here's a model I just ran on the ratio of hosting to participating in the summer Olympics. This is meaningless!pic.twitter.com/snEmahYVDg

      2 replies 3 retweets 35 likes
      Show this thread
    6. Health Nerd‏Verified account @GidMK Jul 28

      We tend to put meta-analyses on a pedestal, but the fact is that statistically aggregating evidence is a total waste of time if that evidence is all bad

      4 replies 19 retweets 114 likes
      Show this thread
    7. Health Nerd‏Verified account @GidMK Jul 28

      Health Nerd Retweeted Health Nerd

      This recent Cochrane review is a perfect example - they looked at the evidence for ivermectin for COVID-19, but because most of it was terrible they only included a few studies in their modelhttps://twitter.com/GidMK/status/1420340231786549253?s=20 …

      Health Nerd added,

      Health NerdVerified account @GidMK
      Cochrane review on ivermectin just dropped. This is the current gold-standard summary: "the reliable evidence available does not support the use ivermectin for treatment or prevention of COVID‐19 outside of well‐designed randomized trials." https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/full …
      Show this thread
      6 replies 12 retweets 60 likes
      Show this thread
    8. Health Nerd‏Verified account @GidMK Jul 28

      This is also where the phrase "garbage in, garbage out" comes from. If your meta-analysis includes numbers from studies that are terrible, the final point estimate is as meaningless as my graph above on the Olympics 🤷‍♂️

      7 replies 8 retweets 90 likes
      Show this thread
    9. Health Nerd‏Verified account @GidMK Jul 28

      Some people think meta-analysis is impressive because it involves fancy statistical software, but it's entirely possible to implement a Dersimonian-Laird inverse-variance model in Excel with a stats textbook and a few hours of time

      10 replies 3 retweets 68 likes
      Show this thread
    10. Steffen Christensen‏ @Wikisteff Jul 29
      Replying to @GidMK

      I used to do meta-analysis by hand in Excel before I learned about meta-analysis.

      1 reply 0 retweets 1 like
      Health Nerd‏Verified account @GidMK Jul 29
      Replying to @Wikisteff

      I sometimes re-run the model in Excel to make sure the default settings aren't broken 😅

      3:24 PM - 29 Jul 2021
      • 1 Like
      • Steffen Christensen
      1 reply 0 retweets 1 like
        1. Steffen Christensen‏ @Wikisteff Jul 29
          Replying to @GidMK

          Now *that's* worth a follow! Right on! ✌️

          0 replies 0 retweets 1 like
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