Something that I keep seeing pop up is the idea that meta-analysis somehow eliminates issues with the underlying research This is just confusingly incorrect
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Hi, here is your unroll: Something that I keep seeing pop up is the idea that meta-analysis… https://threadreaderapp.com/thread/1420529664129261569.html … Enjoy :)
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That's how I learned to do meta analysis as I couldn't afford to buy any software then. Meta analysis math is useful for a lot of things beyond usual metaanalysis. Eg adjusting for confounders.
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I've always agreed with the analogy of a meta-analysis being like where you put a whole group of small turds in a meat grinder and expect that a bar of gold comes out. In reality, you just end up with one giant turd.
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21st century alchemy?
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So I think a more accurate statement is that meta-analysis highly weighted by low quality research is valueless. This might be better than saying meta-analysis is useless. No need to contempt meta-analysis as a method itself.
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Meta-analysis is a simple aggregation of data, and thus is only as valuable or valueless as the underlying research. Gold-standard clinical trials systematically reviewed -> high-value meta-analysis
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Ok, so what would you currently say is the probability that IVM is effective, given your read of the evidence so far?
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Extremely difficult to put an accurate estimate on the probability. I would say that the best current evidence is consistent with either a large benefit or a large harm from taking IVM, and therefore you can't really make a decision based on the data we have
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We are 18 months into a vital pandemic and we still have no out outpatient treatment for those infected - we send them home to "rest" for 2 weeks. How fu**ed up is that when early treatment is crucial in viral infection. There had been almost zero investment by governments into
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