A large, well-done observational trial just found a big mortality benefit for ondansetron in the treatment of COVID-19 I think this is a fascinating case study in how we use observational researchhttps://academic.oup.com/ofid/article/8/7/ofab336/6320906?searchresult=1#275722395 …
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Chance this is going to work is probably nil. This isn't how efficacious drugs are discovered. Likelihood that a hypothesis-free data dredging approach will ID old drugs that might improve COVID outcomes seems v. low. Really don't understand the drug "repurposing" push...
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This looks a lot like data mining. As you say, in any sufficiently large data set correlations will be found
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What about nicotine chewing gum and patches ? ( I don’t smoke or use them)... but I see them touted in fringe neuro enhancement circles. What’s the mechanism?
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Hope a RCT shows it has actual benefit, because it's cheap and readily available.
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Useless for those of us
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