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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Jul 22

      A large, well-done observational trial just found a big mortality benefit for ondansetron in the treatment of COVID-19 I think this is a fascinating case study in how we use observational researchhttps://academic.oup.com/ofid/article/8/7/ofab336/6320906?searchresult=1#275722395 …

      5 replies 41 retweets 125 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Jul 22

      The authors used a huge database of people who'd been treated for COVID-19, and looked at the associations between mortality and 84 drugs or drug classespic.twitter.com/plb2nc3u1q

      1 reply 3 retweets 13 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Jul 22

      They found that metformin, nicotine, fluticasone, SNRI, expectorants and ondasetron reduced the risk of death from COVID-19, but given the potential for residual confounding only focused on ondasetronpic.twitter.com/UwsbMV6KGn

      1 reply 8 retweets 18 likes
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    4. Health Nerd‏Verified account @GidMK Jul 22

      The main conclusion is that we should probably try ondasetron as a treatment for COVID-19 in RCTs, which I think is justifiable based on the studypic.twitter.com/FbEVJINeEB

      2 replies 4 retweets 21 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK Jul 22

      But I think the really interesting part is the initial analysis. It looks like if you test 84 medications for benefit in COVID-19 mortality, 6 positive results will be foundpic.twitter.com/ey7ccuB7si

      3 replies 6 retweets 21 likes
      Show this thread
    6. Dr Darren Saunders‏Verified account @whereisdaz Jul 22
      Replying to @GidMK

      Paging Drs Benjamini and Hochberg

      1 reply 0 retweets 2 likes
      Health Nerd‏Verified account @GidMK Jul 22
      Replying to @whereisdaz

      In this context, I don't think it's necessary to run that sort of correction - they are very open about this being essentially a fishing expedition - but yeh it's interesting how close to the mathematical false positive rate 6/84 is

      4:20 PM - 22 Jul 2021
      • 1 Like
      • Dr Darren Saunders
      1 reply 0 retweets 1 like
        1. Craig Gedye‏ @DrCraigGedye Jul 22
          Replying to @GidMK @whereisdaz

          Trying to think of a mechanism where 5HT3 antagonist would impact. Is this just a case of "getting supportive care in the weird distorted US healthcare system = getting better overall care". We see the same association between Viagra use and prostate cancer in US retro studies.

          0 replies 0 retweets 0 likes
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