A large, well-done observational trial just found a big mortality benefit for ondansetron in the treatment of COVID-19 I think this is a fascinating case study in how we use observational researchhttps://academic.oup.com/ofid/article/8/7/ofab336/6320906?searchresult=1#275722395 …
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If 1,000 people run studies on their databases, and you only really see the positive results published, you'll get the false impression that these drugs work against coronavirus even when the evidence is not good at all
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This is in no way a critique of this specific paper, whose authors appear to have done a fantastic job, but it is a pretty worrying note for the rest of us
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Anyway, ondansetron is a cheap, low-side-effect drug available pretty much everywhere in the world, so if it works for COVID-19 it'd be a brilliant addition to the arsenal
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