A large, well-done observational trial just found a big mortality benefit for ondansetron in the treatment of COVID-19 I think this is a fascinating case study in how we use observational researchhttps://academic.oup.com/ofid/article/8/7/ofab336/6320906?searchresult=1#275722395 …
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Why is this interesting? I think it shows just how important RCTs of interventions for COVID-19 are If you test a bunch of drugs, you'll see some positives
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If 1,000 people run studies on their databases, and you only really see the positive results published, you'll get the false impression that these drugs work against coronavirus even when the evidence is not good at all
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This is in no way a critique of this specific paper, whose authors appear to have done a fantastic job, but it is a pretty worrying note for the rest of us
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Anyway, ondansetron is a cheap, low-side-effect drug available pretty much everywhere in the world, so if it works for COVID-19 it'd be a brilliant addition to the arsenal
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End of conversation
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The issue is that no one was interested in testing known drugs on a large scale, being that it should have been the first (faster), he only focused on the vaccine, knowing that it is a slow process and very difficult to achieve worldwide in short time
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