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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Jul 22

      A large, well-done observational trial just found a big mortality benefit for ondansetron in the treatment of COVID-19 I think this is a fascinating case study in how we use observational researchhttps://academic.oup.com/ofid/article/8/7/ofab336/6320906?searchresult=1#275722395 …

      5 replies 41 retweets 125 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Jul 22

      The authors used a huge database of people who'd been treated for COVID-19, and looked at the associations between mortality and 84 drugs or drug classespic.twitter.com/plb2nc3u1q

      1 reply 3 retweets 13 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Jul 22

      They found that metformin, nicotine, fluticasone, SNRI, expectorants and ondasetron reduced the risk of death from COVID-19, but given the potential for residual confounding only focused on ondasetronpic.twitter.com/UwsbMV6KGn

      1 reply 8 retweets 18 likes
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    4. Health Nerd‏Verified account @GidMK Jul 22

      The main conclusion is that we should probably try ondasetron as a treatment for COVID-19 in RCTs, which I think is justifiable based on the studypic.twitter.com/FbEVJINeEB

      2 replies 4 retweets 21 likes
      Show this thread
      Health Nerd‏Verified account @GidMK Jul 22

      But I think the really interesting part is the initial analysis. It looks like if you test 84 medications for benefit in COVID-19 mortality, 6 positive results will be foundpic.twitter.com/ey7ccuB7si

      4:09 PM - 22 Jul 2021
      • 6 Retweets
      • 21 Likes
      • David Baker Lam Phung Khanh Dieles Stolk Gert van Dijk ⭕📡 Tim Glynn Chris Street, 🇬🇧 MBA, MSc (Medicinal Chemistry) #TeamWissenschaft 🆘 Will Murphy Melissa K Sharp, PhD
      3 replies 6 retweets 21 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK Jul 22

          Thing is, we've been using studies a LOT worse than this one to drive treatments for the whole pandemic. The initial use of ivermectin, HCQ etc in 2020 was based on much less robust evidence than this research

          2 replies 0 retweets 28 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK Jul 22

          Why is this interesting? I think it shows just how important RCTs of interventions for COVID-19 are If you test a bunch of drugs, you'll see some positives

          1 reply 5 retweets 28 likes
          Show this thread
        4. Health Nerd‏Verified account @GidMK Jul 22

          If 1,000 people run studies on their databases, and you only really see the positive results published, you'll get the false impression that these drugs work against coronavirus even when the evidence is not good at all

          1 reply 5 retweets 32 likes
          Show this thread
        5. Health Nerd‏Verified account @GidMK Jul 22

          This is in no way a critique of this specific paper, whose authors appear to have done a fantastic job, but it is a pretty worrying note for the rest of us

          2 replies 2 retweets 27 likes
          Show this thread
        6. Health Nerd‏Verified account @GidMK Jul 22

          Anyway, ondansetron is a cheap, low-side-effect drug available pretty much everywhere in the world, so if it works for COVID-19 it'd be a brilliant addition to the arsenal

          5 replies 5 retweets 43 likes
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        7. End of conversation
        1. New conversation
        2. Dr Darren Saunders‏Verified account @whereisdaz Jul 22
          Replying to @GidMK

          Paging Drs Benjamini and Hochberg

          1 reply 0 retweets 2 likes
        3. Health Nerd‏Verified account @GidMK Jul 22
          Replying to @whereisdaz

          In this context, I don't think it's necessary to run that sort of correction - they are very open about this being essentially a fishing expedition - but yeh it's interesting how close to the mathematical false positive rate 6/84 is

          1 reply 0 retweets 1 like
        4. Show replies
        1. David Baker‏ @DavidBa69494891 Jul 23
          Replying to @GidMK

          But isn't there a statistical problem with this kind of study design?

          0 replies 0 retweets 0 likes
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