7/n Step 2: remove only Elgazzar Immediately, the difference is notable. The primary benefit goes from 60% to 44%, is only marginally statistically significant, and there's no benefit in either Mild or Severe subgroupspic.twitter.com/QHjWGPXLOn
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18/n Therefore, in my opinion, this means that excluding Elgazzar removes any certainty and a lot of significance from this analysis
19/n In other words the conclusion - that moderate-certainty evidence found large reductions in death using ivermectin - is entirely reversed. The certainty is gone, and the reduction in death is likely to be very substantially smaller
20/n Indeed, since the benefit now appears to rest entirely on one very worrisome trial, it is hard to see how we can justify any argument other than that we do not have sufficient information to make a conclusion about ivermectin at this pointpic.twitter.com/39xLhAewpi
21/n I remain optimistic that ivermectin will indeed prove to be a "wonder drug" as Elgazzar claimed, but I simply don't think the evidence to date supports that assertion 
22/n With large randomized trials ongoing, we can only wait for them to finish before making a strong judgement as to whether ivermectin is beneficial It may yet turn out to be fantastic. We simply do not know
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