Gideon is being modest here: this is MASSIVE. A single RCT, which has caused 2 meta-analyses to show benefit of ivermectin, is almost certainly FRAUD. Remove that study, and both meta-analyses (Lawrie and Hill) show NO benefit. Astonishing story.https://twitter.com/GidMK/status/1415764372362649601 …
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Fancy that… it’s like, when you exclude the dodgy trials, there doesn’t seem to be much benefit…
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And if you include the last one...https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06348-5 …
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Thanks for the analysis! A modest benefit remains here, so it's unlikely the issue will be entirely put to bed until findings from PRINCIPLE, but the notion of IVM as magic bullet should die here. PRINCIPLE may well show something along these lines (~20% mortality reduction) /1
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If you exclude both Elgazzar and Niaee the confidence interval goes from ~0.6-1.25. That's a pretty solid null finding imo
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