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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Jul 15

      12/n Problem is, even if this ISN'T the data that the authors actually collected (assuming they collected any data at all), there are still issues in the study For example, they used the wrong statistical tests several timespic.twitter.com/zURo3fpP0g

      1 reply 5 retweets 103 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Jul 15

      13/n Their statistical methodology is...frankly really bizarre They had SPSS but looked up p-values by hand in paper tables? Wildpic.twitter.com/JSA6NMy2Hy

      2 replies 9 retweets 114 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Jul 15

      14/n And let's not forget, pretty much the entire introduction WAS PLAGIARIZED Not good. Not good at all

      1 reply 6 retweets 92 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK Jul 15

      14.5/n Is the study fraud? We may never know. It is really, really hard to prove anything in cases like these, and unless the authors go public we might never know what actually happened beyond the issues that we've seen so far

      1 reply 4 retweets 86 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK Jul 15

      15/n What does this mean more broadly? Well, here's where the story gets both more interesting and somewhat darker This is currently THE BIGGEST RCT of ivermectin. It shows a mortality benefit of 90% That's huge

      1 reply 10 retweets 97 likes
      Show this thread
    6. Health Nerd‏Verified account @GidMK Jul 15

      16/n Being such a big study, it has been included in multiple meta-analyses. With such a vast benefit, it has a very large influence on the meta-analytic resultspic.twitter.com/hkaBoyN0Dq

      1 reply 12 retweets 99 likes
      Show this thread
    7. Health Nerd‏Verified account @GidMK Jul 15

      17/n Indeed, removing ~just this single piece of research~ from recent meta-analyses either mostly or entirely overturns the positive results that they found for ivermectin 👀👀👀pic.twitter.com/Bgw7fGOFyL

      6 replies 28 retweets 150 likes
      Show this thread
    8. Health Nerd‏Verified account @GidMK Jul 15

      18/n Worse still, the paper has been viewed over 130,000 times, and the comments are filled with medical doctors praising the authors and recommending ivermectin based on their results

      2 replies 11 retweets 107 likes
      Show this thread
    9. Health Nerd‏Verified account @GidMK Jul 15

      19/n In other words, this single study has drive ivermectin as a treatment to thousands, perhaps millions, of people And it is either so flawed as to be totally unreliable, or potentially outright fraud

      1 reply 43 retweets 149 likes
      Show this thread
    10. Health Nerd‏Verified account @GidMK Jul 15

      20/n But the story doesn't stop there. Remember, several meta-analyses have included this study in their results. Why would they do that? Well, they thought it was at LOW risk of bias (i.e. high-quality)pic.twitter.com/OG79Rv9MML

      2 replies 15 retweets 131 likes
      Show this thread
      Health Nerd‏Verified account @GidMK Jul 15

      21/n The pretty obvious issue we now have is that this study is clearly filled with problems, yet it's been included in meta-analyses that considered it to be a piece of top-quality research

      5:04 PM - 15 Jul 2021
      • 7 Retweets
      • 104 Likes
      • amyfromarlington moosie gee Mathematiker plädiert für Ruhe und Rationalität Marco Chao sally Zebra Cat robbio 🏳️‍🌈Valour #StayAtHome #BLM Claire Luck
      1 reply 7 retweets 104 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK Jul 15

          22/n At the absolute minimum, studies including this paper should revise their main analysis to exclude it until we have a reasonable explanation for all these issues

          1 reply 5 retweets 94 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK Jul 15

          23/n But we're left with the depressing realization that somehow EVERYONE MISSED THIS I reviewed the study. While I noted concerns with the way it was reported, I never even checked to see if it was fraud

          6 replies 8 retweets 151 likes
          Show this thread
        4. Health Nerd‏Verified account @GidMK Jul 15

          24/n How can it be that a study this problematic was used as evidence to treat 1,000s of people since November 2020, and no one noticed? No one cared?

          8 replies 12 retweets 144 likes
          Show this thread
        5. Health Nerd‏Verified account @GidMK Jul 15

          25/n Anyway, the TL:DR is that the largest study to date of ivermectin for COVID-19, which found a HUGE benefit for the drug, has just been retracted amid very serious concerns about plagiarism and fraud This will echo in the scientific community for years to come

          3 replies 98 retweets 278 likes
          Show this thread
        6. Health Nerd‏Verified account @GidMK Jul 15

          26/n While it is still certainly possible that ivermectin works for COVID-19, this has made a huge dent in that possibility. I await the large studies that are currently being conducted, because we really have no good evidence to rely on

          8 replies 14 retweets 164 likes
          Show this thread
        7. End of conversation

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