9/n You can actually download the file yourself to check, although the website is a morass of malware so it's a bit dicey
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19/n In other words, this single study has drive ivermectin as a treatment to thousands, perhaps millions, of people And it is either so flawed as to be totally unreliable, or potentially outright fraud
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20/n But the story doesn't stop there. Remember, several meta-analyses have included this study in their results. Why would they do that? Well, they thought it was at LOW risk of bias (i.e. high-quality)pic.twitter.com/OG79Rv9MML
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21/n The pretty obvious issue we now have is that this study is clearly filled with problems, yet it's been included in meta-analyses that considered it to be a piece of top-quality research
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22/n At the absolute minimum, studies including this paper should revise their main analysis to exclude it until we have a reasonable explanation for all these issues
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23/n But we're left with the depressing realization that somehow EVERYONE MISSED THIS I reviewed the study. While I noted concerns with the way it was reported, I never even checked to see if it was fraud
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24/n How can it be that a study this problematic was used as evidence to treat 1,000s of people since November 2020, and no one noticed? No one cared?
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25/n Anyway, the TL:DR is that the largest study to date of ivermectin for COVID-19, which found a HUGE benefit for the drug, has just been retracted amid very serious concerns about plagiarism and fraud This will echo in the scientific community for years to come
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26/n While it is still certainly possible that ivermectin works for COVID-19, this has made a huge dent in that possibility. I await the large studies that are currently being conducted, because we really have no good evidence to rely on
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End of conversation
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take. No one reads papers. There was 290k page views of the