7/n One tiny example of the issues with the data - most of the patients in one of the control groups are clones of each other, with very minor changes This is a very common feature of scientific fraudpic.twitter.com/8VlPC5nkJP
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17/n Indeed, removing ~just this single piece of research~ from recent meta-analyses either mostly or entirely overturns the positive results that they found for ivermectin 

pic.twitter.com/Bgw7fGOFyL
18/n Worse still, the paper has been viewed over 130,000 times, and the comments are filled with medical doctors praising the authors and recommending ivermectin based on their results
19/n In other words, this single study has drive ivermectin as a treatment to thousands, perhaps millions, of people And it is either so flawed as to be totally unreliable, or potentially outright fraud
20/n But the story doesn't stop there. Remember, several meta-analyses have included this study in their results. Why would they do that? Well, they thought it was at LOW risk of bias (i.e. high-quality)pic.twitter.com/OG79Rv9MML
21/n The pretty obvious issue we now have is that this study is clearly filled with problems, yet it's been included in meta-analyses that considered it to be a piece of top-quality research
22/n At the absolute minimum, studies including this paper should revise their main analysis to exclude it until we have a reasonable explanation for all these issues
23/n But we're left with the depressing realization that somehow EVERYONE MISSED THIS I reviewed the study. While I noted concerns with the way it was reported, I never even checked to see if it was fraud
24/n How can it be that a study this problematic was used as evidence to treat 1,000s of people since November 2020, and no one noticed? No one cared?
25/n Anyway, the TL:DR is that the largest study to date of ivermectin for COVID-19, which found a HUGE benefit for the drug, has just been retracted amid very serious concerns about plagiarism and fraud This will echo in the scientific community for years to come
26/n While it is still certainly possible that ivermectin works for COVID-19, this has made a huge dent in that possibility. I await the large studies that are currently being conducted, because we really have no good evidence to rely on
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